Anti-TUSC2/FUS1 抗体 (ab70182)
Key features and details
- Rabbit polyclonal to TUSC2/FUS1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-TUSC2/FUS1 antibody
TUSC2/FUS1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TUSC2/FUS1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human TUSC2/FUS1 (internal sequence).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab70182の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/1000. Detects a band of approximately >19 kDa (predicted molecular weight: 12 kDa).
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| 特記事項 |
|---|
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WB
1/500 - 1/1000. Detects a band of approximately >19 kDa (predicted molecular weight: 12 kDa). |
ターゲット情報
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機能
May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. -
組織特異性
Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta. -
配列類似性
Belongs to the TUSC2 family. -
翻訳後修飾
Myristoylation is required for tumor suppressor activity. - Information by UniProt
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参照データベース
- Entrez Gene: 11334 Human
- Omim: 607052 Human
- SwissProt: O75896 Human
- Unigene: 517981 Human
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別名
- C3orf11 antibody
- Fus-1 protein antibody
- FUS1 antibody
see all
画像
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Western blot - Anti-TUSC2/FUS1 antibody (ab70182)All lanes : Anti-TUSC2/FUS1 antibody (ab70182) at 1/500 dilution
Lane 1 : HeLa cell extract
Lane 2 : HeLa cell extract with immunising peptide at 5 µg
Lysates/proteins at 5 µg per lane.
Predicted band size: 12 kDa
Observed band size: <19 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab70182 は 6 報の論文で使用されています。
- Rimkus TK et al. NEDD4 degrades TUSC2 to promote glioblastoma progression. Cancer Lett 531:124-135 (2022). PubMed: 35167936
- Guo Q et al. Circ-EGFR Functions as an Inhibitory Factor in the Malignant Progression of Glioma by Regulating the miR-183-5p/TUSC2 Axis. Cell Mol Neurobiol N/A:N/A (2021). PubMed: 33993369
- Nama S et al. MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression. Sci Rep 9:12718 (2019). PubMed: 31481748
- Liu F et al. TUSC2P suppresses the tumor function of esophageal squamous cell carcinoma by regulating TUSC2 expression and correlates with disease prognosis. BMC Cancer 18:894 (2018). PubMed: 30219035
- Yamamoto K et al. Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression. PLoS One 10:e0137887 (2015). WB ; Human . PubMed: 26367773
- Rutnam ZJ et al. The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs. Nat Commun 5:2914 (2014). WB ; Mouse . PubMed: 24394498