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AB193361

Anti-TTC7B 抗体 [EPR15995]

Anti-TTC7B antibody [EPR15995]

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(1 Publication)

Rabbit Recombinant Monoclonal TTC7B antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication.

別名を表示する

TTC7L1, TTC7B, Tetratricopeptide repeat protein 7B, TPR repeat protein 7B, Tetratricopeptide repeat protein 7-like-1, TPR repeat protein 7-like-1

2 Images
Immunoprecipitation - Anti-TTC7B antibody [EPR15995] (AB193361)
  • IP

Supplier Data

Immunoprecipitation - Anti-TTC7B antibody [EPR15995] (AB193361)

Western blot analysis of TTC7B immunoprecipitated from K562 cell lysate using ab193361 at 1/60 dilution.

Secondary antibody : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution.

Blocking/Dilution buffer : 5% NFDM/TBST.

All lanes:

Immunoprecipitation - Anti-TTC7B antibody [EPR15995] (ab193361)

Predicted band size: 94 kDa

false

Western blot - Anti-TTC7B antibody [EPR15995] (AB193361)
  • WB

Supplier Data

Western blot - Anti-TTC7B antibody [EPR15995] (AB193361)

Blocking/Dilution buffer : 5% NFDM/TBST.

All lanes:

Western blot - Anti-TTC7B antibody [EPR15995] (ab193361) at 1/1000 dilution

Lane 1:

K562 cell lysate at 20 µg

Lane 2:

Human fetal brain lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 94 kDa

Observed band size: 94 kDa

false

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-TTC7B antibody [EPR15995] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR15995

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IP

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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組合せ製品

Primary Antibodies

AB111565

Anti-PI4KA antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PI4KA antibody (AB111565)

  • 0
  • 0
Primary Antibodies

AB126605

Anti-FTO antibody [EPR6894]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-FTO antibody [EPR6894] (AB126605)

  • 4
  • 3
Primary Antibodies

AB195352

Anti-METTL3 antibody [EPR18810]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry - Anti-METTL3 antibody [EPR18810] (AB195352)

  • 5
  • 8
Assay Kits

AB245880

H&E Staining Kit (Hematoxylin and Eosin)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - H&E Staining Kit (Hematoxylin and Eosin) (AB245880)

  • 5
  • 3
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/60", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
出荷温度
Conditional Ambient
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TTC7B also known as Tetratricopeptide Repeat Domain 7B is a protein with a mass of approximately 114 kDa. Mechanically it contains several tetratricopeptide repeat (TPR) motifs that facilitate protein-protein interactions. This protein is expressed in many tissues with notable levels in the liver and kidney. Its role is to help with various cellular processes likely through binding with other proteins to form functional complexes.
Biological function summary

TTC7B contributes to cellular functions through its involvement in the phosphatidylinositol-4 kinase pathway. This pathway is important for the regulation of cell signaling and membrane trafficking. TTC7B is part of the GOLPH3/TTC7B complex which maintains proper Golgi function and morphology an essential aspect for vesicular transport and signal transduction.

Pathways

The phosphatidylinositol signaling and inositol phosphate metabolism pathways require TTC7B's participation. These pathways are critical for various cellular processes including cell growth survival and communication. TTC7B interfaces with proteins such as PI4KA and FAM126A which are important for phosphatidylinositol 4-phosphate synthesis impacting overall pathway functionality.

Improper TTC7B function can associate with Golgi function-related disorders. Conditions such as Lenz-Majewski hyperostotic dwarfism have connections to the dysregulation of pathways involving TTC7B. In these contexts proteins like PI4KA also interact in the disease mechanism illustrating TTC7B's significance in maintaining cellular and physiological balance.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions (PubMed : 26571211).
See full target information TTC7B
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature genetics 57:680-693 PubMed40069506

2025

Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Long Liang,Xinwei Kuang,Yi He,Lin Zhu,Poyee Lau,Xin Li,Dingan Luo,Lan Gong,Wenbin Zhou,Fanglin Zhang,Xiaowei Liang,Zhuofeng Li,Bin Hu,Dandan Liu,Tao Ding,Hui Li,Shuang Zhao,Juan Su,Mien-Chie Hung,Jing Liu,Hong Liu,Xiang Chen
View all publications
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Abcam product promise

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