AB62461

Anti-TRPC6 抗体

Name: Anti-TRPC6 抗体 (ab62461) | Abcam
Brand: Abcam Limited
SKU: AB62461
Price: 86000 JPY
Availability: InStock
Rating: 5 (1 reviews)

Anti-TRPC6 antibody

(1 Review)

(23 Publications)

Rabbit Polyclonal TRPC6 antibody. Suitable for ICC and reacts with Human samples. Cited in 23 publications. Immunogen corresponding to Synthetic Peptide within Human TRPC6.

別名を表示する

TRP6, TRPC6, Short transient receptor potential channel 6, TrpC6, Transient receptor protein 6, TRP-6

2 Images

Supplier Data

Immunocytochemistry - Anti-TRPC6 antibody (AB62461)

ICC analysis of K562 (human chronic myelogenous leukemia cell line from bone marrow) cells stained for TRPC6 (red) using ab62461 (5 μg/ml).

Supplier Data

Immunocytochemistry - Anti-TRPC6 antibody (AB62461)

ICC analysis of K562 (human chronic myelogenous leukemia cell line from bone marrow) cells stained for TRPC6 using ab62461 (2 μg/ml).

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

ICC

applications

免疫原

Synthetic Peptide within Human TRPC6. The exact immunogen used to generate this antibody is proprietary information.

Q9Y210

特異性

This antibody does potentially cross-react with TRPC3.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "2-5 µg/mL", "ICC-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The TRPC6 also known as Transient Receptor Potential Cation Channel Subfamily C Member 6 functions as a non-selective cation channel permeable to calcium ions. It facilitates calcium entry into cells impacting cellular signaling and homeostasis. TRPC6 has a molecular mass of about 106 kDa. Expression of TRPC6 is broad but is notably significant in tissues such as brain heart lung and skeletal muscle where it influences diverse functions.

Biological function summary

TRPC6 is integral to various cellular processes especially those involving calcium-dependent signaling pathways. It is known to form heteromeric complexes with other TRPC subfamily members such as TRPC3 and TRPC7 which modulates its function. These interactions are important for the regulation of intracellular calcium levels impacting cellular excitability contraction and growth.

Pathways

TRPC6 is involved in the phospholipase C (PLC) pathway and subsequent inositol triphosphate (IP3) signaling. This signaling cascade is vital for the regulation of calcium release from intracellular stores. TRPC6 also has a notable role in the Ras homolog family member A (RhoA) signaling pathway which affects cytoskeletal dynamics and cell motility. Inside these pathways proteins like IP3 receptors and RhoA GTPases are closely related to TRPC6 function.

TRPC6 is associated with conditions like focal segmental glomerulosclerosis (FSGS) and pulmonary hypertension. Mutations in TRPC6 can lead to abnormal regulation of calcium homeostasis in kidney cells contributing to FSGS. Moreover TRPC6 overactivity in pulmonary vascular smooth muscle cells has been implicated in the pathology of pulmonary hypertension. In these conditions TRPC6's interaction with calcineurin and other calcium-dependent signaling proteins plays a critical role in disease progression.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Forms a receptor-activated non-selective calcium permeant cation channel (PubMed : 19936226, PubMed : 23291369, PubMed : 26892346, PubMed : 9930701). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed : 26892346). Does not seem to be activated by intracellular calcium store depletion.

See full target information TRPC6

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文献 (23)

Recent publications for all applications. Explore the full list and refine your search

ImmunoTargets and therapy 13:735-748 PubMed39691169

2024

TRPC6 is a Biomarker for Prognosis and Immunotherapy of Stomach Adenocarcinoma Based on Bioinformatic Analysis and Experimental Validation.

Applications

Unspecified application

Species

Unspecified reactive species

Xingchi Hu,Hongwei Wang,Haitao Sun,Jingxin Zhang,ZhenXiong Ye,Zhenhua Huang

Kidney360 4:1454-1466 PubMed37265366

2023

Insights into the Regulation of GFR by the Keap1-Nrf2 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Kengo Kidokoro,Hiroyuki Kadoya,David Z I Cherney,Megumi Kondo,Yoshihisa Wada,Reina Umeno,Seiji Kishi,Hajime Nagasu,Kojiro Nagai,Takafumi Suzuki,Tamaki Sasaki,Masayuki Yamamoto,Yashpal S Kanwar,Naoki Kashihara

Pharmaceutics 14: PubMed36297636

2022

Polydatin Ameliorates High Fructose-Induced Podocyte Oxidative Stress via Suppressing HIF-1α/NOX4 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Ding,Chuanfeng Tang,Wei Wang,Ying Pan,Ruiqing Jiao,Lingdong Kong

Stem cell research & therapy 13:401 PubMed35932080

2022

Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress.

Applications

Unspecified application

Species

Unspecified reactive species

Li Wang,Hong Liang,Bingjing Sun,Jing Mi,Xianqin Tong,Yuhui Wang,Meihua Chen,Liming Yu,Jie Pan,Shangfeng Liu,Yan-Jun Liu,Yuehua Liu

Frontiers in cardiovascular medicine 8:731890 PubMed34912856

2021

Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjia Peng,Shuai Li,Shiyue Chen,Jiacheng Yang,Ze Sun

Frontiers in cell and developmental biology 8:594283 PubMed33604333

2021

TRPC6 Attenuates Cortical Astrocytic Apoptosis and Inflammation in Cerebral Ischemic/Reperfusion Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Liu,Manli Chen,Kun Lin,Xuwu Xiang,Jing Yang,Yueying Zheng,Xiaoxing Xiong,Shengmei Zhu

Molecular biology reports 48:1453-1464 PubMed33606151

2021

Astragaloside IV inhibits palmitic acid-induced apoptosis through regulation of calcium homeostasis in mice podocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Yingjun Zang,Shuang Liu,Aili Cao,Xiangyu Shan,Wenjuan Deng,Zhijun Li,Hao Wang,Yunman Wang,Li Wang,Wen Peng

International journal of molecular sciences 22: PubMed33467715

2021

Lithium Reduces Migration and Collagen Synthesis Activity in Human Cardiac Fibroblasts by Inhibiting Store-Operated Ca Entry.

Applications

Unspecified application

Species

Unspecified reactive species

Pao-Huan Chen,Cheng-Chih Chung,Yuan-Feng Lin,Yu-Hsun Kao,Yi-Jen Chen

Shock (Augusta, Ga.) 55:244-255 PubMed33026218

2020

Overexpressed lncRNA AC068039.4 Contributes to Proliferation and Cell Cycle Progression of Pulmonary Artery Smooth Muscle Cells Via Sponging miR-26a-5p/TRPC6 in Hypoxic Pulmonary Arterial Hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhan Qin,Boqian Zhu,Linqing Li,Dong Wang,Yong Qiao,Bo Liu,Erfei Luo,Jiantong Hou,Gaoliang Yan,Chengchun Tang

Journal of diabetes research 2020:3634974 PubMed33015191

2020

Protective Role of Tangshen Formula on the Progression of Renal Damage in Mice by TRPC6/Talin1 Pathway in Podocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Wang,Xuefei Tian,Wei'e Zhou,Yan Wang,Hailing Zhao,Jialin Li,Xuefeng Zhou,Haojun Zhang,Tingting Zhao,Ping Li

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TRPC6 抗体

Anti-TRPC6 antibody

Immunocytochemistry - Anti-TRPC6 antibody (AB62461)

Immunocytochemistry - Anti-TRPC6 antibody (AB62461)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (23)

Abcam product promise