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AB153810

Anti-TRPC4AP 抗体

Anti-TRPC4AP antibody

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(1 Publication)

Rabbit Polyclonal TRPC4AP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRPC4AP aa 50 to C-terminus.

別名を表示する

C20orf188, TRRP4AP, TRPC4AP, Short transient receptor potential channel 4-associated protein, Trp4-associated protein, Trpc4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Fragment Protein within Human TRPC4AP aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8TEL6

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組合せ製品

Primary Antibodies

AB155226

Anti-UXS-1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UXS-1 antibody (AB155226)

  • 0
  • 0
Primary Antibodies

AB106707

Anti-DCAF12 antibody

Immunocytochemistry - Anti-DCAF12 antibody (AB106707)

  • 0
  • 0
Proteins & Peptides

AB98145

Recombinant Human Glutamine Synthetase protein (His tag N-Terminus)

Western blot - Recombinant Human Glutamine Synthetase protein (His tag N-Terminus) (AB98145)

  • 0
  • 0
Primary Antibodies

AB56400

Anti-COP1 antibody [1E4]

BOND RX™ Validated

Western blot - Anti-COP1 antibody [1E4] (AB56400)

  • 4
  • 4
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TRPC4AP also known as TRPC4-associated protein acts mechanically as an adaptor protein that interacts with the TRPC4 ion channel. It plays a role in the regulation of calcium influx through this channel. With a molecular weight of approximately 76 kDa TRPC4AP has expression in various tissues including the brain and heart. Its interaction with TRPC4 affects cellular responses to calcium signals important for various cellular processes.
Biological function summary

TRPC4AP assists in anchoring TRPC4 channels to other signaling proteins impacting calcium-dependent signaling pathways. It often forms part of a multiprotein complex that modulates the activity and localization of these channels. This coordination affects cellular calcium homeostasis and influences processes such as muscle contraction neuronal signaling and endothelial barrier function.

Pathways

TRPC4AP contributes to processes like the phosphatidylinositol signaling system involving calcium release. It associates with proteins like calmodulin and IP3 receptors in this pathway. Additionally TRPC4AP plays a role in the calcium-dependent protein kinase (CaMK) pathway where it interacts with proteins critical for phosphorylation events controlled by calcium signaling.

TRPC4AP has relevance in cardiovascular diseases and neurological disorders. Its disruption can lead to altered calcium signaling contributing to conditions such as heart failure and certain neurodegenerative diseases. TRPC4AP interacts with proteins linked to these conditions such as calcium-binding proteins and other signaling molecules involved in the affected pathways.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed : 20551172, PubMed : 29779948). The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed : 20551172, PubMed : 29779948). The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed : 29779948). The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed : 29779948). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (By similarity).
See full target information TRPC4AP
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 293:6064-6074 PubMed29483192

2018

Alternative splicing variant of the scaffold protein APPL1 suppresses hepatic adiponectin signaling and function.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda K Galan-Davila,Jiyoon Ryu,Kun Dong,Yang Xiao,Zhe Dai,Deling Zhang,Zhi Li,Amanda M Dick,Kevin D Liu,Amrita Kamat,Min Lu,Qunfeng Dong,Feng Liu,Lily Q Dong
View all publications
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Abcam product promise

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