JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB220287

Anti-TRIM9 抗体

Anti-TRIM9 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal TRIM9 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRIM9 aa 100-200.

別名を表示する

KIAA0282, RNF91, TRIM9, E3 ubiquitin-protein ligase TRIM9, RING finger protein 91, RING-type E3 ubiquitin transferase TRIM9, Tripartite motif-containing protein 9

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-TRIM9 antibody (AB220287)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-TRIM9 antibody (AB220287)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized RH-30 cells labeling TRIM9 with ab220287 at 4 μg/ml (green).

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human TRIM9 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9C026

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TRIM9 also known as Tripartite Motif Containing 9 is an E3 ubiquitin ligase with a mass of approximately 68 kDa. This protein adds ubiquitin to substrate proteins tagging them for proteasomal degradation or altering their activity. TRIM9 contains a RING domain B-box type zinc finger and coiled-coil region typical of the TRIM family proteins. It is widely expressed in the nervous system with high levels found in the brain highlighting its significance in neural processes.
Biological function summary

The TRIM9 protein regulates axon pathfinding and synapse formation influencing neural network development. TRIM9 forms complexes with other proteins to modulate cytoskeletal dynamics affecting neuron shape and connectivity. By interacting with proteins like DCC (Deleted in Colorectal Carcinoma) TRIM9 plays a role in guiding axons during neural circuit formation. This interaction is essential for creating proper neuronal connections and ensuring functional communication within the brain.

Pathways

TRIM9 emerges as an important regulator in the Netrin-1 signaling pathway critical for axonal guidance. This pathway involves interaction with DCC a receptor for Netrin-1 influencing axonal steering decisions. Additionally TRIM9 participates in the ubiquitination pathway affecting protein stability and cellular localization that modulates various signaling cascades within neurons. By manipulating these pathways TRIM9 assists in neural development and plasticity.

Alterations in TRIM9 expression or function correlate with neurological conditions such as schizophrenia and autism spectrum disorders. Dysfunctional TRIM9-mediated pathways might disrupt neural circuit development contributing to the cognitive and social impairments associated with these disorders. Other proteins like DCC also share connections with these disorders indicating a network of interactions where TRIM9 influences disease pathology.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
See full target information TRIM9
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The FEBS journal 292:1950-1971 PubMed39871113

2025

Transcriptomic signatures and network-based methods uncover new senescent cell anti-apoptotic pathways and senolytics.

Applications

Unspecified application

Species

Unspecified reactive species

Samael Olascoaga,Mina Konigsberg,Jesús Espinal-Enríquez,Hugo Tovar,Félix Matadamas-Martínez,Jaime Pérez-Villanueva,Norma Edith López-Diazguerrero
View all publications
style
left-column
style
left-column
style
right-column

組合せ製品

Primary Antibodies

AB125068

Anti-LAMP2A antibody [EPR4207(2)] - Lysosome Marker

RabMAb|Recombinant|Lab Essentials|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LAMP2A antibody [EPR4207(2)] - Lysosome Marker (AB125068)

  • 4
  • 4
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB47062

Anti-TRIM33 antibody

Immunocytochemistry/ Immunofluorescence - Anti-TRIM33 antibody (AB47062)

  • 0
  • 0
Primary Antibodies

AB300439

Anti-Senataxin antibody [EPR24137-74]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Senataxin antibody [EPR24137-74] (AB300439)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com