Anti-TRF1 抗体
Anti-TRF1 antibody
2
(4 Reviews)
|
(40 Publications)
Rabbit Polyclonal TRF1 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 40 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TERF1.
別名を表示する
PIN2, TRBF1, TRF, TRF1, TERF1, Telomeric repeat-binding factor 1, NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1
- WB
Supplier Data
Western blot - Anti-TRF1 antibody (AB1423)
Western blot labelling TRF1 in HL-60 (Human promyelocytic leukemia cell line) whole cell extract using ab1423 at 1/2000. A single band at 60-65 kD is detected.
All lanes:
Western blot - Anti-TRF1 antibody (ab1423) at 1/2000 dilution
All lanes:
HL-60 (Human promyelocytic leukemia cell line) whole cell extract
Predicted band size: 50 kDa
Observed band size: 60-65 kDa
false
- ICC
Supplier Data
Immunocytochemistry - Anti-TRF1 antibody (AB1423)
The cells in the first image are probably in a stage of the cell cycle where the signal is not so clear. In this image the antibody is shown to recognise the same signal but staining is shown as 20-30 spots (punctate foci).
- ICC
Unknown
Immunocytochemistry - Anti-TRF1 antibody (AB1423)
Cells transfected with a TRF1-GFP contruct. On the left : immunofluorescence with the anti-TRF1 antibody used at 1/300, with a Texas Red-conjugated secondary antibody. In the centre : fluorescence from the GFP. Right : merge of both images showing overlap of GFP fluorescence and antibody staining.
Reactivity data
出荷温度及び保存条件
製品の状態
精製度
バッファー組成
出荷温度
短期保存期間
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TRF1 contributes to the stabilization of telomere structure and regulates telomere length. TRF1 is a part of the shelterin complex which also includes proteins such as TRF2 POT1 TIN2 RAP1 and TPP1. The shelterin complex prevents the telomeres from being recognized as DNA damage and regulates their replicative processes. TRF1 interacts directly with telomeric DNA influencing replication and modulating access to telomerase the enzyme responsible for telomere elongation.
Pathways
TRF1 plays a significant role in telomere maintenance and the cell cycle. The protein is critical in the DNA damage response pathway where it prevents unwanted DNA repair activities at telomeres. In this context TRF1 interacts with proteins like ATM and ATR which are important for signaling and responding to DNA damage. TRF1's interaction with these pathways helps maintain genomic stability and cellular homeostasis.
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ターゲットの情報
文献 (40)
Recent publications for all applications. Explore the full list and refine your search
Methods in molecular biology (Clifton, N.J.) 2444:141-159 PubMed35290636
2022
Applications
Unspecified application
Species
Unspecified reactive species
Nature communications 13:760 PubMed35140211
2022
Applications
Unspecified application
Species
Unspecified reactive species
IET nanobiotechnology 16:14-24 PubMed34862858
2021
Applications
Unspecified application
Species
Unspecified reactive species
Metallomics : integrated biometal science 13: PubMed34021581
2021
Applications
ChIP
Species
Human
RNA biology 18:2261-2277 PubMed33749516
2021
Applications
WB
Species
Human
Frontiers in cell and developmental biology 9:617225 PubMed33553179
2021
Applications
IF
Species
Mouse
International journal of molecular sciences 21: PubMed31877678
2019
Applications
IF, IHC, IHC, WB, WB, IF
Species
Human, Human, Mouse, Human, Mouse, Mouse
Aging 11:1965-1976 PubMed30926765
2019
Applications
ICC/IF
Species
Mouse
Nature communications 9:3583 PubMed30181605
2018
Applications
WB
Species
Human
Molecular and cellular biology 38: PubMed29581185
2018
Applications
ChIP
Species
Human
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