Anti-TRAP/CD40L 抗体 [AP-MAB0820] (ab83050)
Key features and details
- Armenian hamster monoclonal [AP-MAB0820] to TRAP/CD40L
- Suitable for: IHC-Fr, Inhibition Assay, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-TRAP/CD40L antibody [AP-MAB0820]
TRAP/CD40L 一次抗体 製品一覧 -
製品の詳細
Armenian hamster monoclonal [AP-MAB0820] to TRAP/CD40L -
由来種
Armenian hamster -
アプリケーション
適用あり: IHC-Fr, Inhibition Assay, Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse TRAP/CD40L. Activated Mouse Th1 cells.
Database link: P27548 -
特記事項
This monoclonal is azide-free & contains an extremely low level of LPS (< 0.002EU/µg IgG).This hamster monoclonal may be used to inhibit the activation of T and B lymphocytes in vitro and to study antigen-specific lymphocyte responses in vivo.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Lyophilized -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading... -
特記事項（精製）
The IgG fraction of culture supernatant was purified by Protein A/Gaffinity chromatography. -
一次抗体 備考
This hamster monoclonal may be used to inhibit the activation of T and B lymphocytes in vitro and to study antigen-specific lymphocyte responses in vivo. -
ポリ/モノ
モノクローナル -
クローン名
AP-MAB0820 -
アイソタイプ
IgG -
研究分野
関連製品
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab83050の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
|
|
| Inhibition Assay |
Use at an assay dependent concentration.
|
|
| Flow Cyt |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
|
Inhibition Assay
Use at an assay dependent concentration. |
|
Flow Cyt
Use at an assay dependent concentration. |
ターゲット情報
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機能
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. -
組織特異性
Specifically expressed on activated CD4+ T-lymphocytes. -
関連疾患
Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. -
配列類似性
Belongs to the tumor necrosis factor family. -
翻訳後修飾
The soluble form derives from the membrane form by proteolytic processing.
N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
Not O-glycosylated. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 21947 Mouse
- SwissProt: P27548 Mouse
- Unigene: 4861 Mouse
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別名
- CD 40L antibody
- CD154 antibody
- CD40 antigen ligand antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (0)
ab83050 は論文での使用が確認できていません。
