AB231063

Anti-TRAIL 抗体

Name: Anti-TRAIL 抗体 (ab231063) | Abcam
Brand: Abcam Limited
SKU: AB231063
Price: 74000 JPY
Availability: InStock

Anti-TRAIL antibody

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(7 Publications)

Rabbit Polyclonal TRAIL antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 7 publications.

別名を表示する

CD253, APO2L, TRAIL, TNFSF10, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, TNF-related apoptosis-inducing ligand, Apo-2L, Protein TRAIL

7 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAIL antibody (AB231063)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAIL antibody (AB231063)

Formalin-fixed, paraffin-embedded rat ovary tissue stained for TRAIL with ab231063 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAIL antibody (AB231063)

Formalin-fixed, paraffin-embedded rat stomach tissue stained for TRAIL with ab231063 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAIL antibody (AB231063)

Formalin-fixed, paraffin-embedded rat intestine tissue stained for TRAIL with ab231063 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAIL antibody (AB231063)

Formalin-fixed, paraffin-embedded rat kidney tissue stained for TRAIL with ab231063 at 20 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAIL antibody (AB231063)

Formalin-fixed, paraffin-embedded rat testis tissue stained for TRAIL with ab231063 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-TRAIL antibody (AB231063)

All lanes:

Western blot - Anti-TRAIL antibody (ab231063) at 3 µg/mL

All lanes:

MCF7 (Human breast adenocarcinoma cell line) cell lysate

Secondary

All lanes:

HRP-linked Guinea pig Anti-Rabbit at 1/2000 dilution

Predicted band size: 32 kDa

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Supplier Data

Western blot - Anti-TRAIL antibody (AB231063)

All lanes:

Western blot - Anti-TRAIL antibody (ab231063) at 2 µg/mL

All lanes:

recombinant rat TRAIL protein

Predicted band size: 32 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Rat, Human

アプリケーション

WB, IHC-P

applications

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代替製品

Primary Antibodies

AB9959

Anti-TRAIL antibody

Sandwich ELISA - Anti-TRAIL antibody (AB9959)

Primary Antibodies

AB65121

Anti-TRAIL antibody

Western blot - Anti-TRAIL antibody (AB65121)

Primary Antibodies

AB183474

PE Anti-TRAIL antibody [2E5]

Primary Antibodies

AB2219

Anti-TRAIL antibody [2E5]

Primary Antibodies

AB95532

PE Anti-TRAIL antibody [N2B2]

Flow Cytometry - PE Anti-TRAIL antibody [N2B2] (AB95532)

Primary Antibodies

AB231265

Anti-TRAIL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAIL antibody (AB231265)

Primary Antibodies

AB2056

Anti-TRAIL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRAIL antibody (AB2056)

Primary Antibodies

AB95531

Biotin Anti-TRAIL antibody [N2B2]

Flow Cytometry - Biotin Anti-TRAIL antibody [N2B2] (AB95531)

組合せ製品

Assay Kits

AB46074

Human TRAIL ELISA Kit (CD253)

ELISA - Human TRAIL ELISA Kit (CD253) (AB46074)

Primary Antibodies

AB8416

Anti-DR5 antibody

Immunocytochemistry - Anti-DR5 antibody (AB8416)

Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

Primary Antibodies

AB207327

Anti-Albumin antibody [EPR20195]

20ul selling size|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Albumin antibody [EPR20195] (AB207327)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

精製に関する特記事項

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

バッファー組成

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TRAIL also known as TNF-related apoptosis-inducing ligand plays an important role in inducing apoptosis. This protein has a mass of around 32 kDa and is expressed across various tissues including immune cells. TRAIL interacts with specific receptors on the cell surface to initiate a signaling cascade that results in programmed cell death. It is an attractive therapeutic target because of its selective ability to induce apoptosis in cancer cells while sparing most normal cells.

Biological function summary

TRAIL's function extends beyond inducing cell death. It is an important member of the tumor necrosis factor (TNF) superfamily which regulates immune responses and inflammation. TRAIL can form a homotrimeric complex allowing it to bind effectively to death receptors on target cells specifically DR4 and DR5 triggering a series of downstream signaling events. This interaction is significant in modulating immune surveillance and tumor suppression.

Pathways

TRAIL is integral to both intrinsic and extrinsic apoptosis pathways. Through these pathways TRAIL is closely related to FADD and caspase-8 which are important for apoptosis induction. The extrinsic pathway involves binding to TRAIL death receptors leading to DISC formation while the intrinsic pathway involves mitochondrial events mediated by members of the Bcl-2 protein family.

TRAIL has a significant connection with cancer and autoimmune diseases. TRAIL plays a dual role in cancer where it acts as a tumor suppressor but can also promote tumor progression if cancer cells become resistant to its effects. In cancer TRAIL’s interaction with proteins like FLIP can alter the apoptotic potential of the cells. In autoimmune diseases TRAIL's dysregulation can contribute to tissue damage due to increased immune activity highlighting its complex role in maintaining immune balance.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed : 10549288, PubMed : 26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

See full target information TNFSF10

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Regenerative therapy 30:1-8 PubMed40476159

2025

Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus.

Applications

Unspecified application

Species

Unspecified reactive species

Masayuki Fukumoto,Akihiko Soyama,Daisuke Miyamoto,Takanobu Hara,Hajime Matsushima,Hajime Imamura,Mampei Yamashita,Tomohiko Adachi,Kengo Kanetaka,Susumu Eguchi

Cell death & disease 15:595 PubMed39152108

2024

Autophagy modulation attenuates sorafenib resistance in HCC induced in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yomna Elleithi,Amal El-Gayar,Mohamed N Amin

Orphanet journal of rare diseases 18:66 PubMed36959587

2023

Comprehensive analysis of autophagy-related gene expression profiles identified five gene biomarkers associated with immune infiltration and advanced plaques in carotid atherosclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chi Ma,Taoyuan Lu,Yanyan He,Dehua Guo,Lin Duan,Rufeng Jia,Dongyang Cai,Tao Gao,Zhongcan Chen,Binghua Xue,Tianxiao Li,Yingkun He

Journal of immunology research 2023:5293677 PubMed36969496

2023

Network-Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA-Transcriptome.

Applications

Unspecified application

Species

Unspecified reactive species

Guohui Wu,Yusheng Guo,Yang Liu,Xiangsheng Cai,Tanggang Deng,Tianchu Pei,Long Huang,Kai Chen,Xuan Pan

Oxidative medicine and cellular longevity 2020:6196398 PubMed32566090

2020

Moderate Mechanical Stimulation Protects Rats against Osteoarthritis through the Regulation of TRAIL via the NF-B/NLRP3 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Yang,Yang Wang,Yawei Kong,Xiaoning Zhang,He Zhang,Xinyuan Feng,Ziyuan Wang,Peng Gao,Mingyue Yan,Lunhao Bai,Feng Li

Nature communications 10:5183 PubMed31729368

2019

A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Nadine D Arnold,Josephine A Pickworth,Laura E West,Sarah Dawson,Joana A Carvalho,Helen Casbolt,Adam T Braithwaite,James Iremonger,Lewis Renshall,Volker Germaschewski,Matthew McCourt,Philip Bland-Ward,Hager Kowash,Abdul G Hameed,Alexander M K Rothman,Maria G Frid,A A Roger Thompson,Holly R Evans,Mark Southwood,Nicholas W Morrell,David C Crossman,Moira K B Whyte,Kurt R Stenmark,Christopher M Newman,David G Kiely,Sheila E Francis,Allan Lawrie

Experimental and therapeutic medicine 17:41-50 PubMed30651763

2019

Tumor necrosis factor-related apoptosis-inducing ligand inhibits the growth and aggressiveness of colon carcinoma via the exogenous apoptosis signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyan Gong,Weicai Cheng,Yong Wang

View all publications

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Abcam product promise

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