AB169052

Anti-TRA2A 抗体

Name: Anti-TRA2A 抗体 (ab169052) | Abcam
Brand: Abcam Limited
SKU: AB169052
Price: 76000 JPY
Availability: InStock

Anti-TRA2A antibody

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(2 Publications)

Mouse Polyclonal TRA2A antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TRA2A.

別名を表示する

Transformer-2 protein homolog alpha, TRA-2 alpha, TRA2-alpha, Transformer-2 protein homolog A, TRA2A

5 Images

Immunocytochemistry/ Immunofluorescence - Anti-TRA2A antibody (AB169052)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TRA2A antibody (AB169052)

Immunofluorescent analysis of HeLa cells labeling TRA2A with ab169052 at 10 µg/ml.

Unknown

Western blot - Anti-TRA2A antibody (AB169052)

All lanes:

Western blot - Anti-TRA2A antibody (ab169052) at 1 µg/mL

All lanes:

Raw 267.4 cell lysate at 50 µg

Secondary

All lanes:

Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

Predicted band size: 33 kDa

true

Unknown

Western blot - Anti-TRA2A antibody (AB169052)

All lanes:

Western blot - Anti-TRA2A antibody (ab169052) at 1 µg/mL

All lanes:

HepG2 cell lysate at 50 µg

Secondary

All lanes:

Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

Predicted band size: 33 kDa

true

Unknown

Western blot - Anti-TRA2A antibody (AB169052)

All lanes:

Western blot - Anti-TRA2A antibody (ab169052) at 1 µg/mL

All lanes:

NIH 3T3 cell lysate at 50 µg

Secondary

All lanes:

Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

Predicted band size: 33 kDa

true

Unknown

Western blot - Anti-TRA2A antibody (AB169052)

All lanes:

Western blot - Anti-TRA2A antibody (ab169052) at 1 µg/mL

Lane 1:

TRA2A transfected 293T cell lysate at 15 µL

Lane 2:

non 293T cell lysate at 15 µL

Secondary

All lanes:

Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

Predicted band size: 33 kDa

true

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Human

アプリケーション

ICC/IF, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human TRA2A.

Q13595

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TRA2A also known as transformer 2 alpha homolog is an RNA-binding protein involved in numerous cellular processes. This protein has a molecular weight of approximately 31 kDa. It is expressed in many tissues including the brain and testes. TRA2A binds to specific RNA sequences modulating splicing events and affecting the choice of splice sites. It belongs to the serine/arginine-rich protein family which plays key roles in the regulation of both alternative and constitutive splicing.

Biological function summary

TRA2A influences gene expression and transcript variants by engaging in complex interactions. It acts as part of the spliceosome machinery which is a large ribonucleoprotein complex responsible for splicing pre-mRNA. TRA2A ensures precise removal of introns and ligation of exons producing different mRNA isoforms. These isoforms translate into functionally distinct proteins influencing cellular activity.

Pathways

TRA2A participates in the mRNA processing pathway influencing genetic output by regulating splice site selection. TRA2A connects to the MAPK signaling pathway as it is known to interact with proteins like SAM68 which also affects mRNA splicing. This connectivity with other proteins highlights the regulatory network's complexity ensuring accurate gene expression profiles.

TRA2A has been implicated in cancer and neurodegenerative disorders. Altered expression and splicing activity of TRA2A contribute to oncogenesis as seen in breast cancer where abnormal splicing can drive tumor progression. TRA2A also impacts neurological conditions interplaying with proteins like tau in Alzheimer's disease where aberrant splicing plays a part in disease pathology. Understanding these links offers potential therapeutic angles for targeting TRA2A-related pathways.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.

See full target information TRA2A

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Virology journal 19:176 PubMed36329446

2022

Tripartite motif-containing protein 46 accelerates influenza A H7N9 virus infection by promoting K48-linked ubiquitination of TBK1.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Su,Xian-Tian Lin,Shuai Zhao,Xiao-Qin Zheng,Yu-Qing Zhou,Lan-Lan Xiao,Hui Chen,Zheng-Yu Zhang,Li-Jun Zhang,Xiao-Xin Wu

Journal of advanced research 39:103-117 PubMed35777901

2022

miR-155 down-regulation protects the heart from hypoxic damage by activating fructose metabolism in cardiac fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Zhang,Hong Zhang,Zhan Yang,Xin-Hua Zhang,Qing Miao,Min Li,Tian-Ying Zhai,Bin Zheng,Jin-Kun Wen

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TRA2A 抗体

Anti-TRA2A antibody

Immunocytochemistry/ Immunofluorescence - Anti-TRA2A antibody (AB169052)

Western blot - Anti-TRA2A antibody (AB169052)

Western blot - Anti-TRA2A antibody (AB169052)

Western blot - Anti-TRA2A antibody (AB169052)

Western blot - Anti-TRA2A antibody (AB169052)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise