Anti-TPH2 抗体 (ab111828)
Key features and details
- Rabbit polyclonal to TPH2
- Suitable for: IP
- Reacts with: Rat
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-TPH2 antibody
TPH2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TPH2 -
由来種
Rabbit -
アプリケーション
適用あり: IPmore details -
種交差性
交差種: Rat -
免疫原
Synthetic peptide:
RRGLSLDSAVPEDHQL
, corresponding to N terminal amino acids 15-30 of Human TPH2. -
ポジティブ･コントロール
- IP: Sprague-Dawley rat brains
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.1% Sodium azide
Constituent: 0.1% BSA -
Concentration information loading... -
精製度
Affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab111828の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IP |
1/1000.
|
| 特記事項 |
|---|
|
IP
1/1000. |
ターゲット情報
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組織特異性
Brain specific. -
パスウェイ
Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. -
関連疾患
Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders. -
配列類似性
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain. - Information by UniProt
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参照データベース
- Entrez Gene: 317675 Rat
- SwissProt: Q8CGU9 Rat
- Unigene: 28510 Rat
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別名
- MGC138871 antibody
- ADHD7 antibody
- FLJ37295 antibody
see all
画像
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Immunoprecipitation - Anti-TPH2 antibody (ab111828)
Immunoprecipitation analysis of Raphe Nuclei isolated from Sprague-Dawley, precipitating ab111828 coupled to magnetic beads, which was introduced to whole cell extracts at room temperature for 15 mins. Immunoprecipitated proteins were assessed by Western blotting.
Lane 1 (Positive Control): Non-immunoprecipitated brain lysates were probed with ab111828.
Lane 2 (ab111828 Ms TPH2): Immunoprecipitated Proteins
Lane 3 (Sheep TPH2 antibody): Immunoprecipitated Proteins
Lane 4 (Negative Control => Anti-Tyrosine Hydroxylase antibody): Immunoprecipitated proteins
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (16)
ab111828 は 16 報の論文で使用されています。
- Schapira I et al. Measuring tryptophan dynamics using fast scan cyclic voltammetry at carbon fiber microelectrodes with improved sensitivity and selectivity. RSC Adv 13:26203-26212 (2023). PubMed: 37671005
- Wang XY et al. A glutamatergic DRN-VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice. Nat Commun 14:5124 (2023). PubMed: 37612268
- Chang WY et al. 5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome. Lab Invest 102:1023-1037 (2022). PubMed: 35585132
- Uchida S et al. A Discrete Glycinergic Neuronal Population in the Ventromedial Medulla That Induces Muscle Atonia during REM Sleep and Cataplexy in Mice. J Neurosci 41:1582-1596 (2021). PubMed: 33372061
- Singh M et al. 22(R)-hydroxycholesterol for dopaminergic neuronal specification of MSCs and amelioration of Parkinsonian symptoms in rats. Cell Death Discov 7:13 (2021). PubMed: 33454721