Anti-TNF Receptor II 抗体 [HM102] (ab7369)
Key features and details
- Rat monoclonal [HM102] to TNF Receptor II
- Suitable for: IHC-Fr, IP, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2a
製品の概要
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製品名
Anti-TNF Receptor II antibody [HM102]
TNF Receptor II 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [HM102] to TNF Receptor II -
由来種
Rat -
特異性
Mouse TNF-R II and the soluble receptor. -
アプリケーション
適用あり: IHC-Fr, IP, Flow Cytmore details -
種交差性
交差種: Mouse -
エピトープ
Extra-cellular part of the receptor. -
特記事項
The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-alpha.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.1% Sodium azide
Constituent: 1% BSA -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
HM102 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab7369の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
|
|
| IP |
Use at an assay dependent concentration.
|
|
| Flow Cyt |
Use at an assay dependent concentration.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
| 特記事項 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. |
|
Flow Cyt
Use at an assay dependent concentration. ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. -
配列類似性
Contains 4 TNFR-Cys repeats. -
翻訳後修飾
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 21938 Mouse
- SwissProt: P25119 Mouse
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別名
- CD120b antibody
- p75 antibody
- p75 TNF receptor antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab7369 は 3 報の論文で使用されています。
- Fu XQ et al. Tumor necrosis factor alpha mediates neuromuscular synapse elimination. Cell Discov 6:9 (2020). PubMed: 32140252
- Fan J et al. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res 35:47-59 (2011). PubMed: 21039629
- Tesz GJ et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem 282:19302-12 (2007). Mouse . PubMed: 17500068