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AB8097

Anti-TNF alpha 抗体 [V1q(H8)]

Anti-TNF alpha antibody [V1q(H8)]

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(4 Publications)

Rat Monoclonal TNF alpha antibody. Suitable for Flow Cyt, Neut and reacts with Mouse samples. Cited in 4 publications.

別名を表示する

Tnfa, Tnfsf2, Tnf, Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

V1q(H8)

アイソタイプ

IgD

キャリアフリー

No

交差種

Mouse

アプリケーション

Flow Cyt, Neut

applications

特異性

Anti-mouse TNF-a reacts with both natural and recombinant TNF-a and shows neutralizing activity.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "Neut" : {"fullname" : "Neutralising", "shortname":"Neut"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>Stains the extracellular domain. The CHO cells were fixed in PBA containing 0.2 % formaldehyde before staining.</p>", "Neut-species-checked": "guaranteed", "Neut-species-dilution-info": "", "Neut-species-notes": "<p>The antibody was functionally tested by neutralization of the cytopathic effect of cytotoxin in the L929 TNF bioassay. The biological activity of the antibody can be defined as the concentration of V1q required to neutralize 100 U/ml of TNF/cytotoxin.</p>" } } }

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4

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こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

お客様の実験に適するかご確認いただくため、必ず製品データシートをご確認いただくことをお勧めいたします。ご不明点等ございましたら、テクニカルサポートチームまでお問い合わせください。

出荷温度及び保存条件

製品の状態
Liquid
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

ターゲットの情報

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed : 25586176). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (PubMed : 32741026).. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
See full target information Tnf

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 9:e1003096 PubMed23300453

2013

TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection.

Applications

Neut

Species

Mouse

Elena Helk,Hannah Bernin,Thomas Ernst,Harald Ittrich,Thomas Jacobs,Joerg Heeren,Frank Tacke,Egbert Tannich,Hannelore Lotter

The Journal of investigative dermatology 127:2259-67 PubMed17460730

2007

Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Itamar Goren,Elke Müller,Dana Schiefelbein,Urs Christen,Josef Pfeilschifter,Heiko Mühl,Stefan Frank

The American journal of pathology 168:765-77 PubMed16507892

2006

Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha.

Applications

Unspecified application

Species

Unspecified reactive species

Itamar Goren,Elke Müller,Josef Pfeilschifter,Stefan Frank

Journal of immunology (Baltimore, Md. : 1950) 145:3762-6 PubMed2246512

1990

Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.

Applications

Unspecified application

Species

Unspecified reactive species

B Echtenacher,W Falk,D N Männel,P H Krammer
View all publications

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

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