Anti-TMS1/ASC 抗体 (ab111852)
Key features and details
- Goat polyclonal to TMS1/ASC
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-TMS1/ASC antibody
TMS1/ASC 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to TMS1/ASC -
由来種
Goat -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human TMS1/ASC aa 150-250 (C terminal).
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ポジティブ･コントロール
- Human Liver and tonsil tissues; HeLa lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 99% Tris buffered saline -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab111852の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 22 kDa.
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| IHC-P |
Use a concentration of 2.5 µg/ml.
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| 特記事項 |
|---|
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WB
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 22 kDa. |
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IHC-P
Use a concentration of 2.5 µg/ml. |
ターゲット情報
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機能
Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. -
組織特異性
Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells. -
配列類似性
Contains 1 CARD domain.
Contains 1 DAPIN domain. -
ドメイン
Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain. -
翻訳後修飾
Phosphorylated. -
細胞内局在
Cytoplasm. Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures. - Information by UniProt
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参照データベース
- Entrez Gene: 29108 Human
- Omim: 606838 Human
- SwissProt: Q9ULZ3 Human
- Unigene: 499094 Human
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別名
- Apoptosis associated speck like protein containing a CARD antibody
- Apoptosis-associated speck-like protein containing a CARD antibody
- ASC antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMS1/ASC antibody (ab111852)
ab111852, at 2.5µg/ml, staining TMS1/ASC in Formalin-fixed, Paraffin-embedded Human Liver tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMS1/ASC antibody (ab111852)ab111852, at 2.5µg/ml, staining TMS1/ASC in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry.
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Western blot - Anti-TMS1/ASC antibody (ab111852)Anti-TMS1/ASC antibody (ab111852) at 1 µg/ml + HeLa lysate at 35 µg
Developed using the ECL technique.
Predicted band size: 22 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab111852 は 1 報の論文で使用されています。
- Wang X et al. The lncRNA XIST/miR-150-5p/c-Fos axis regulates sepsis-induced myocardial injury via TXNIP-modulated pyroptosis. Lab Invest 101:1118-1129 (2021). PubMed: 34045679