Anti-TMPRSS4 抗体 (ab82176)
Key features and details
- Goat polyclonal to TMPRSS4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-TMPRSS4 antibody
TMPRSS4 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to TMPRSS4 -
由来種
Goat -
特異性
ab82176 is expected to recognize both reported isoforms (NP_063947.1 and NP_001077416.1). -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse
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免疫原
Synthetic peptide:
DSTRCNADDAYQGE
, corresponding to internal sequence amino acids 352-365 of Human TMPRSS4 (NP_063947.1) (or aa347-360 of NP_001077416.1). -
ポジティブ･コントロール
- WB: HEK-293 cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
ab82176 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab82176の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 48 kDa.
1 hour primary incubation is recommended for this product. |
| 特記事項 |
|---|
|
WB
Use a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 48 kDa. 1 hour primary incubation is recommended for this product. |
ターゲット情報
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機能
Probable protease. Seems to be capable of activating ENaC. -
組織特異性
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract. -
配列類似性
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 56649 Human
- Entrez Gene: 214523 Mouse
- Omim: 606565 Human
- SwissProt: Q9NRS4 Human
- SwissProt: Q8VCA5 Mouse
- Unigene: 161985 Human
- Unigene: 436756 Mouse
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別名
- UNQ776/PRO1570 antibody
- CAPH2 antibody
- Channel-activating protease 2 antibody
see all
画像
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Western blot - Anti-TMPRSS4 antibody (ab82176)Anti-TMPRSS4 antibody (ab82176) at 0.5 µg/ml + HEK-293 (human epithelial cell line from embryonic kidney) cell lysate (in RIPA buffer) at 35 µg
Predicted band size: 48 kDa
Observed band size: 48 kDaDetected by chemiluminescence. 1 hour primary incubation.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab82176 は 3 報の論文で使用されています。
- Xiao H et al. Type II transmembrane serine proteases 4 (TMPRSS4) promotes proliferation, invasion and epithelial-mesenchymal transition in endometrial carcinoma cells (HEC1A and Ishikawa) via activation of MAPK and AKT. Anim Cells Syst (Seoul) 25:211-218 (2021). PubMed: 34408809
- Fan X et al. The upregulation of TMPRSS4, partly ascribed to the downregulation of miR-125a-5p, promotes the growth of human lung adenocarcinoma via the NF-?B signaling pathway. Int J Oncol 53:148-158 (2018). PubMed: 29750426
- Li XM et al. Overexpression of TMPRSS4 promotes tumor proliferation and aggressiveness in breast cancer. Int J Mol Med 39:927-935 (2017). PubMed: 28259959