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AB121333

Anti-TMIGD2/IGPR1 抗体

Anti-TMIGD2/IGPR1 antibody

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(2 Publications)

Rabbit Polyclonal TMIGD2/IGPR1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMIGD2 aa 1-150.

別名を表示する

CD28H, IGPR1, UNQ3059/PRO9879, TMIGD2, Transmembrane and immunoglobulin domain-containing protein 2, CD28 homolog, Immunoglobulin and proline-rich receptor 1, IGPR-1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMIGD2/IGPR1 antibody (AB121333)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMIGD2/IGPR1 antibody (AB121333)

ab121333, at 1/50, staining TMIGD2/IGPR1 in paraffin embedded Human duodenum tissue by Immunohistochemistry.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human TMIGD2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q96BF3

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組合せ製品

Primary Antibodies

AB209242

Anti-B7H4 antibody [EPR20236]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-B7H4 antibody [EPR20236] (AB209242)

  • 0
  • 0
Primary Antibodies

AB315994

Anti-HHLA2 antibody [EPR26395-88]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HHLA2 antibody [EPR26395-88] (AB315994)

  • 0
  • 0
Primary Antibodies

AB134161

Anti-CD276 antibody [EPNCIR122]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-CD276 antibody [EPNCIR122] (AB134161)

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  • 0
Primary Antibodies

AB192033

Anti-Nectin-4 antibody [EPR15613-68]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Nectin-4 antibody [EPR15613-68] (AB192033)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TMIGD2 also known as IGPR1 (Immuno-Glycosylation Promoting Receptor 1) is a protein that functions as a transmembrane receptor. It has a molecular weight of approximately 50 kDa. TMIGD2 is expressed on the surface of endothelial cells and some lymphocytes notably T cells. The protein has a specific expression pattern which restricts it to certain tissues indicating its specialized role in cellular communication and interaction.
Biological function summary

This protein functions in the regulation of cell-cell adhesions impacting cell signaling and the maintenance of endothelial barriers. TMIGD2/IGPR1 does not function alone but associates homophilically binding to itself on adjacent cells to mediate cellular communication. This interaction plays a pivotal role in stabilizing intercellular connections which are essential for the proper function of vascular systems. Studies suggest its role in modulating immune cell interactions and migration.

Pathways

TMIGD2/IGPR1 interfaces significantly with the cellular adhesion and immune response pathways. It is involved in adhesive interactions that are integral to the function of these pathways. TMIGD2 interacts with proteins involved in the vascular endothelial growth factor (VEGF) pathway influencing angiogenesis and vascular integrity. Additionally it has links to the cell signaling pathways involving integrins which serve as important mediators in cellular attachment and migration.

Research associates TMIGD2/IGPR1 with vascular-related conditions such as atherosclerosis and inflammation-related diseases. Its expression patterns influence endothelial cell response and immune cell trafficking important elements in these conditions. In atherosclerosis the protein's interaction with adhesion molecules like ICAM-1 and VCAM-1 can alter the inflammatory environment influencing disease progression. In inflammatory diseases TMIGD2's modulatory effects on immune cell dynamics can exacerbate or alleviate disease states depending on the context.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
See full target information TMIGD2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 15:1524861 PubMed40061889

2025

Prognostic significance of the inhibitory-to-stimulatory immune checkpoint ratio in patients with breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Chuangang Tang,Xiang Hu,Dawei Hao,Tao Chen,Pei Wang,Changwen Li,Chengling Chen,Yongcheng Li,Xiaowen Hao,Zeng Yuan

Biochemical genetics 59:453-474 PubMed33098307

2020

miR-491-3p is Downregulated in Retinoblastoma and Inhibit Tumor Cells Growth and Metastasis by Targeting SNN.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Hu,Ming Zhao,Li Li,Jie Ding,Yu-Min Gui,Tan-Wei Wei
View all publications
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Abcam product promise

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