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AB105417

Anti-TMEM59 抗体

Anti-TMEM59 antibody

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(2 Publications)

Rabbit Polyclonal TMEM59 antibody. Suitable for WB, IF, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TMEM59.

別名を表示する

C1orf8, HSPC001, UNQ169/PRO195, TMEM59, Transmembrane protein 59, Liver membrane-bound protein

3 Images
Immunohistochemistry paraffin embedded sections - Anti-TMEM59 antibody (AB105417)
  • IHC-P

Unknown

Immunohistochemistry paraffin embedded sections - Anti-TMEM59 antibody (AB105417)

Immunohistochemistry of TMEM59 in human kidney tissue with ab105417 at 2.5 µg/ml.

Immunofluorescence - Anti-TMEM59 antibody (AB105417)
  • IF

Unknown

Immunofluorescence - Anti-TMEM59 antibody (AB105417)

Immunofluorescence of TMEM59 in Human kidney tissue with ab105417 at 20 ug/mL.

Western blot - Anti-TMEM59 antibody (AB105417)
  • WB

Unknown

Western blot - Anti-TMEM59 antibody (AB105417)

All lanes:

Western blot - Anti-TMEM59 antibody (ab105417) at 1 µg/mL

Lane 1:

Human kidney tissue lysate at 15 µg

Lane 2:

Human kidney tissue lysate at 15 µg with blocking peptide

Predicted band size: 36 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IF, IHC-P, WB

applications

免疫原

Synthetic Peptide within Human TMEM59. The exact immunogen used to generate this antibody is proprietary information.

Q9BXS4

特異性

Multiple isoforms of TMEM59 are known to exist. This antibody is predicted to not cross-react with other TMEM family members.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IF" : {"fullname" : "Immunofluorescence", "shortname":"IF"}, "IHCP" : {"fullname" : "Immunohistochemistry paraffin embedded sections", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IF-species-checked": "testedAndGuaranteed", "IF-species-dilution-info": "", "IF-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TMEM59 also known as Transmembrane Protein 59 plays a role in protein glycosylation and modulation of the cell surface expression of certain proteins. It has a molecular mass of approximately 39 kDa. TMEM59 is expressed in a variety of tissues including the brain lung and kidney where it localizes to the endoplasmic reticulum and Golgi apparatus. The protein's structure suggests membrane spanning properties that contribute to its function in cell regulation.
Biological function summary

TMEM59 contributes to proper neuronal function by modulating the cell surface expression of proteins involved in neuron-neuron communications. This regulation has implications for membrane protein function and synaptic stability. TMEM59 participates in certain bionetworks interacting with protein complexes that influence cell signaling pathways. Such interactions play significant roles in controlling protein trafficking and localization within cells impacting the cellular response to environmental signals.

Pathways

TMEM59 influences processes like the Wnt signaling pathway affecting cell fate decisions and embryonic development. It interacts with proteins such as β-catenin and affects their stability and function. TMEM59 also participates in the autophagy-dependent pathways modulating cellular mechanisms involved in the degradation of damaged proteins and organelles therefore maintaining cellular homeostasis.

TMEM59 has links to neurodegenerative diseases including Alzheimer's disease and schizophrenia. TMEM59's regulation of proteins like APP (Amyloid precursor protein) is significant. Disruptions in its function may contribute to aberrant protein aggregation commonly seen in Alzheimer's disease pathology. Additionally disruptions in TMEM59 expression or function could affect cognitive processes and synaptic connections related to schizophrenia as it influences the trafficking of receptor proteins important for synaptic signaling.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed : 23376921, PubMed : 27273576). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed : 20427278). Inhibits APP transport to the cell surface and further shedding (PubMed : 20427278).
See full target information TMEM59
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of genomics 2023:9942663 PubMed37719786

2023

An Analysis of the Gene Expression Associated with Lymph Node Metastasis in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hongjie Yang,Jiafei Liu,Peishi Jiang,Peng Li,Yuanda Zhou,Zhichun Zhang,Qingsheng Zeng,Min Wang,Luciena Xiao Xiao,Xipeng Zhang,Yi Sun,Siwei Zhu

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:2824-2834 PubMed35169020

2022

The ZIP3 Zinc Transporter Is Localized to Mossy Fiber Terminals and Is Required for Kainate-Induced Degeneration of CA3 Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Milos Bogdanovic,Hila Asraf,Noa Gottesman,Israel Sekler,Elias Aizenman,Michal Hershfinkel
View all publications
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代替製品

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Immunohistochemistry paraffin embedded sections - Anti-TMEM59 antibody (AB97597)

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組合せ製品

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Primary Antibodies

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Western blot - Anti-TMEM59L antibody [EPR14975] (AB185227)

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Primary Antibodies

AB246222

Anti-CD16 antibody [EPR22409-124]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD16 antibody [EPR22409-124] (AB246222)

  • 5
  • 3
Primary Antibodies

AB134929

Anti-Human Kappa Chain antibody [EPR5539-71-8]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Human Kappa Chain antibody [EPR5539-71-8] (AB134929)

  • 0
  • 0

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