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AB109468

Anti-TMEM205 抗体

Anti-TMEM205 antibody

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Goat Polyclonal TMEM205 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human TMEM205 aa 100-150.

別名を表示する

UNQ501/PRO1018, TMEM205, Transmembrane protein 205

1 Images
Western blot - Anti-TMEM205 antibody (AB109468)
  • WB

Unknown

Western blot - Anti-TMEM205 antibody (AB109468)

Primary incubation was 1 hour.

All lanes:

Western blot - Anti-TMEM205 antibody (ab109468) at 0.03 µg/mL

All lanes:

Human Pancreas lysate (in RIPA buffer) at 35 µg

Predicted band size: 21 kDa

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Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human TMEM205 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.

Q6UW68

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.03-0.1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab109468 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
バッファー組成
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 0.5% BSA, 0.05% Tris buffered saline
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TMEM205 also known as Transmembrane Protein 205 is an integral membrane protein involved in transportation processes across cellular membranes. It weighs approximately 26 kDa and primarily resides in the plasma membranes of cells. TMEM205 is expressed in a broad range of tissues with notable expression in the liver kidney lung and heart. This protein contributes to cellular processes by participating in the movement of various molecules across the cell envelope.
Biological function summary

It plays a role in cellular export mechanisms and likely intersects with the multidrug resistance (MDR) pathways. It does not form part of any larger protein complex but functions independently to modulate cellular response to different substances. Its presence associates with cellular export systems and impacts the ability of the cell to handle xenobiotics which are foreign chemical substances found within an organism.

Pathways

TMEM205 functions in the xenobiotic metabolism regulatory pathways and cellular stress response pathways. It interacts with proteins such as MDR1 (P-glycoprotein) and ABC transporters which are significant in drug resistance mechanisms. These interactions suggest its involvement in detoxification processes allowing cells to expel potentially harmful compounds and adapt to environmental changes.

TMEM205 has been connected to chemotherapy resistance in cancer notably influencing treatment outcomes. Its association with proteins like MDR1 contributes to this resistance by expelling chemotherapeutic agents from cells making treatment less effective. Additionally research indicates it may play a role in certain liver dysfunctions linking it to overall hepatic health and challenging the management of related disorders. Understanding TMEM205's function can aid in developing strategies to counteract drug resistance and support liver health.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
See full target information TMEM205
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Product
Primary Antibodies

AB224516

Anti-TMEM205 antibody

primary-antibodies

tmem205-antibody-ab224516

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