AB185337

Anti-TMEM119 抗体 - Microglial marker

Name: Anti-TMEM119 抗体 - Microglial marker (ab185337) | Abcam
Brand: Abcam Limited
SKU: AB185337
Price: 56000 JPY
Availability: InStock
Rating: 2 (13 reviews)

Anti-TMEM119 antibody - Microglial marker

Lab Essentials
詳細を見る

(13 Reviews)

(12 Publications)

Rabbit Polyclonal TMEM119 antibody. Microglia marker. Suitable for IHC-P and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM119 aa 100-200.

別名を表示する

PSEC0199, UNQ731/PRO1415, TMEM119, Transmembrane protein 119, Osteoblast induction factor, OBIF

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Immunohistochemistry analysis of Human tonsil tissue labeling TMEM119 with ab185337 at 1/50 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Paraffin-embedded human testis tissue stained for TMEM119 using ab185337 at 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Paraffin-embedded human liver tissue stained for TMEM119 using ab185337 at 1/50 dilution in immunohistochemical analysis.

Negative control.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Paraffin-embedded human cerebral cortex tissue stained for TMEM119 using ab185337 at 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Paraffin-embedded human lymph node tissue stained for TMEM119 using ab185337 at 1/50 dilution in immunohistochemical analysis.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human TMEM119 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q4V9L6

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

style

left-column

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TMEM119 also known as transmembrane protein 119 plays a role in cell membrane dynamics. It has a molecular mass of approximately 35 kDa. TMEM119 is specifically expressed in microglia in the central nervous system. Microglia serve essential functions in brain homeostasis and immune response. Given its expression profile TMEM119 serves as a marker to identify microglia especially in research focused on neurological tissues. Researchers often utilize techniques like microglial flow cytometry and microglial staining for identification and quantification of microglial populations often in frozen marker studies.

Biological function summary

TMEM119 regulates signaling pathways that maintain microglial identity and function but does not typically form part of larger complexes. It modulates microglial activation states and influences responses to central nervous system injury and inflammation. As a membrane protein it may interact with other surface molecules although specific binding partners are not well-characterized in current literature. Researchers value TMEM119 as a reliable marker in studies aiming to distinguish brain-resident microglia from infiltrating peripheral macrophages.

Pathways

TMEM119 functions as a modulator within inflammatory and neuroimmune pathways. It plays roles in the NF-kB signaling and the neuroinflammatory cascade. Its relationship with proteins like CD68 and Iba1 indicates it may influence pathways tied to immune responses and phagocytosis within nervous system contexts. Understanding the interactions and co-expression of TMEM119 with these proteins helps clarify its contribution to neuroimmune functions.

TMEM119 links with neurological conditions such as Alzheimer's disease and multiple sclerosis. Altered expression of TMEM119 appears in disease states potentially contributing to pathogenesis through disrupted inflammatory responses. Its association with proteins such as TREM2 in Alzheimer's suggests that TMEM119 may play indirect roles in the progression of neurodegeneration. Furthermore high TMEM119 levels in pathological samples provide insights into microglial involvement in disease progression and potential targets for therapeutic interventions.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed : 20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).

See full target information TMEM119

style

left-column

文献 (12)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 21:47 PubMed38347588

2024

Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Wonjae Sung,Min-Young Noh,Minyeop Nahm,Yong Sung Kim,Chang-Seok Ki,Young-Eun Kim,Hee-Jin Kim,Seung Hyun Kim

Biological psychiatry 95:676-686 PubMed37573007

2023

Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment.

Applications

Unspecified application

Species

Unspecified reactive species

Steven D Sheridan,Joy E Horng,Hana Yeh,Liam McCrea,Jennifer Wang,Ting Fu,Roy H Perlis

Methods in molecular biology (Clifton, N.J.) 2683:53-68 PubMed37300766

2023

Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.

Applications

Unspecified application

Species

Unspecified reactive species

Shih-Wei Chen,Yu-Hui Wong

Scientific reports 13:7907 PubMed37193782

2023

Cannabidiol inhibits neuroinflammatory responses and circuit-associated synaptic loss following damage to a songbird vocal pre-motor cortical-like region.

Applications

Unspecified application

Species

Unspecified reactive species

Mark Tripson,Karen Litwa,Ken Soderstrom

Frontiers in molecular neuroscience 16:1128545 PubMed37251648

2023

Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model.

Applications

Unspecified application

Species

Unspecified reactive species

Guoli Zheng,Anna-Kathrin Harms,Mohamed Tail,Hao Zhang,Alan Nimmo,Thomas Skutella,Karl Kiening,Andreas Unterberg,Klaus Zweckberger,Alexander Younsi

Journal of neuroscience research 101:3-19 PubMed36200530

2022

Development of a novel bioengineered 3D brain-like tissue for studying primary blast-induced traumatic brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Dustin M Snapper,Bianca Reginauld,Volha Liaudanskaya,Vincent Fitzpatrick,Yeonho Kim,Irene Georgakoudi,David L Kaplan,Aviva J Symes

International forum of allergy & rhinology 13:242-254 PubMed35984636

2022

Eosinophil-derived interferon-γ drives transmembrane protein 119-induced new bone formation in chronic rhinosinusitis with nasal polyps.

Applications

Unspecified application

Species

Unspecified reactive species

Sungsin Jo,Bong Joon Jin,Seung Hoon Lee,Hye-Ryeong Jo,Joo Mi Park,Kyung-Gyun Hwang,Mina Rho,Tae-Hwan Kim,Seok Hyun Cho

Scientific reports 12:12606 PubMed35871163

2022

Human iPSC co-culture model to investigate the interaction between microglia and motor neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Björn F Vahsen,Elizabeth Gray,Ana Candalija,Kaitlyn M L Cramb,Jakub Scaber,Ruxandra Dafinca,Antigoni Katsikoudi,Yinyan Xu,Lucy Farrimond,Richard Wade-Martins,William S James,Martin R Turner,Sally A Cowley,Kevin Talbot

Brain pathology (Zurich, Switzerland) 32:e13101 PubMed35748290

2022

Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiki Hase,Kamar E Ameen-Ali,Rachel Waller,Julie E Simpson,Charlotte Stafford,Ayushi Mahesh,Lucy Ryan,Lucy Pickering,Caroline Bodman,Mai Hase,Delphine Boche,Karen Horsburgh,Stephen B Wharton,Raj N Kalaria

Frontiers in neurology 10:728 PubMed31354608

2019

Human Inner Ear Immune Activity: A Super-Resolution Immunohistochemistry Study.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Liu,Charlotta Kämpfe Nordström,Niklas Danckwardt-Lillieström,Helge Rask-Andersen

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TMEM119 抗体 - Microglial marker

Anti-TMEM119 antibody - Microglial marker

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM119 antibody - Microglial marker (AB185337)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (12)

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Abcam product promise