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AB37071

Anti-TLR5 抗体

Anti-TLR5 antibody

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(1 Publication)

Rabbit Polyclonal TLR5 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TLR5.

別名を表示する

TIL3, TLR5, Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-TLR5 antibody (AB37071)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TLR5 antibody (AB37071)

ab37071 at 10μg/ml staining TLR5 in THP-1 cells by ICC/IF

Western blot - Anti-TLR5 antibody (AB37071)
  • WB

Unknown

Western blot - Anti-TLR5 antibody (AB37071)

Lane 1:

Western blot - Anti-TLR5 antibody (ab37071) at 0.5 µg/mL

Lane 2:

Western blot - Anti-TLR5 antibody (ab37071) at 1 µg/mL

Lane 3:

Western blot - Anti-TLR5 antibody (ab37071) at 2 µg/mL

All lanes:

THP 1 cell lysate at 15 µg

Predicted band size: 97 kDa

Observed band size: 65 kDa,97 kDa

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Immunocytochemistry/ Immunofluorescence - Anti-TLR5 antibody (AB37071)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-TLR5 antibody (AB37071)

Immunofluorescence of TLR5 in THP1 cells using ab37071 at 10 ug/ml.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF, WB

applications

免疫原

Synthetic Peptide within Human TLR5. The exact immunogen used to generate this antibody is proprietary information.

O60602

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
精製に関する特記事項
Purified by affinity chromatography
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Toll-like receptor 5 (TLR5) also known as CD285 is a protein that functions mechanically as a pattern recognition receptor. It has a mass of about 98 kDa and is expressed mainly in the tissues of the lung intestine and urogenital tract. TLR5 recognizes pathogen-associated molecular patterns specifically identifying and binding to flagellin a protein component of bacterial flagella. This engagement initiates a signaling cascade that results in an immune response.
Biological function summary

This receptor plays a central role in the innate immune system. TLR5 is part of a complex network of receptors that detect microbial infections and activate immune defense. When TLR5 binds to flagellin it triggers the production of inflammatory cytokines and activation of adaptive immune responses. This interaction helps in mobilizing immune cells to the site of infection providing the body with a robust defense mechanism against bacterial pathogens.

Pathways

TLR5 activation is an important component of the NF-kB signaling and MAPK pathways. These pathways lead to the transcription of genes involved in inflammation and immune response. TLR5 interacts with MyD88 an adaptor protein to facilitate the downstream signaling cascade. This involvement links TLR5 to not only NF-kB pathway but also connects it to other Toll-like receptors further integrating the immune signaling network.

TLR5 has been connected to inflammatory bowel disease and chronic obstructive pulmonary disease (COPD). Abnormal TLR5 signaling can lead to excessive inflammation contributing to these conditions. In COPD TLR5 and its associated cytokines can exacerbate lung inflammation while in inflammatory bowel disease dysregulation may trigger improper intestinal immune responses. Research into TLR5's role in these diseases can illuminate potential therapeutic targets.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed : 11323673, PubMed : 18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed : 29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed : 11489966, PubMed : 20855887). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity).
See full target information TLR5
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 25:104407 PubMed35663028

2022

Neuregulin-1/ErbB4 signaling modulates HRP2-induced damage to brain cortical organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Adriana Harbuzariu,Annette Nti,Keri Oxendine Harp,Juan C Cespedes,Adel Driss,Jonathan K Stiles
View all publications
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代替製品

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Primary Antibodies

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  • 0
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Primary Antibodies

AB115603

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR5 antibody (AB115603)

  • 0
  • 0

組合せ製品

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  • 0
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Secondary Antibodies

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Primary Antibodies

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Abcam product promise

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