AB12085

Anti-TLR3 抗体 [TLR3.7]

Name: Anti-TLR3 抗体 [TLR3.7] (ab12085) | Abcam
Brand: Abcam Limited
SKU: AB12085
Price: 76000 JPY
Availability: InStock
Rating: 4 (1 reviews)

Anti-TLR3 antibody [TLR3.7]

(1 Review)

(14 Publications)

Mouse Monoclonal TLR3 antibody. Suitable for Flow Cyt (Intra) and reacts with Human samples. Cited in 14 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TLR3.

別名を表示する

CD283, Toll-like receptor 3, TLR3

1 Images

Flow Cytometry (Intracellular) - Anti-TLR3 antibody [TLR3.7] (AB12085)

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-TLR3 antibody [TLR3.7] (AB12085)

Flow cytometric detection of human TLR3 on THP-1 cells. Red line represents the isotype control and the black line represents ab12085 at 10 μg/ml.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

TLR3.7

アイソタイプ

IgG1

キャリアフリー

交差種

Human

アプリケーション

Flow Cyt (Intra)

applications

免疫原

Recombinant Full Length Protein corresponding to Human TLR3.

O15455

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10", "FlowCytIntra-species-notes": "See paper by Matsumoto et al, 2003. <a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody" }, "Mouse": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" }, "Dog": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "FlowCytIntra-species-checked": "predicted", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

精製に関する特記事項

0.2 µm filtered

バッファー組成

Constituents: PBS, 0.1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TLR3 also known as Toll-like receptor 3 is a protein that plays an important role in immune response mechanisms. With a molecular mass of around 104 kDa TLR3 is part of the Toll-like receptor family and expresses mostly in immune cells including dendritic cells and macrophages. It locates mainly on the endosomal membrane where it recognizes double-stranded RNA (dsRNA) which is often a sign of viral infection. TLR3 initiates signaling cascades that lead to the activation of important immune transcription factors.

Biological function summary

TLR3 acts as a sensor for viral and endogenous dsRNA. This receptor forms part of the innate immune system serving as a first line of defense against microbial infections. Upon encountering its ligand TLR3 undergoes conformational changes which allow interaction with the adaptor protein TRIF (TIR-domain-containing adapter-inducing interferon-β). This interaction triggers a downstream signaling cascade that leads to the production of type I interferons and pro-inflammatory cytokines which are essential for mounting an effective antiviral response.

Pathways

TLR3 engages in important signaling cascades like the NF-kB and IRF3 pathways. These pathways are activated by the TRIF-dependent pathway which is unique among the Toll-like receptors. TLR3 influences the expression of genes involved in the inflammatory response and apoptosis. The interactions of TLR3 with other proteins such as MyD88 and IRAK1 are indirect as TLR3 does not depend on the usual MyD88-dependent pathway. This specificity makes TLR3 a critical component in pathogen recognition and response strategies within the immune system.

TLR3 has connections with several conditions primarily viral infections and autoimmune disorders like systemic lupus erythematosus (SLE). Mutations or dysregulation of TLR3 may lead to altered immune responses contributing to the pathogenesis of these diseases. TLR3's association with proteins like TRIF and IRF3 is significant in understanding its role in these conditions. Ongoing research investigates TLR3's potential as a therapeutic target to modulate immune responses in disease states.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.

See full target information TLR3

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文献 (14)

Recent publications for all applications. Explore the full list and refine your search

PloS one 16:e0260835 PubMed34882718

2021

Key role of Extracellular RNA in hypoxic stress induced myocardial injury.

Applications

Unspecified application

Species

Unspecified reactive species

Saumya Bhagat,Indranil Biswas,Md Iqbal Alam,Madiha Khan,Gausal A Khan

Thrombosis and haemostasis 121:1448-1463 PubMed33706396

2021

Protective Role of Activated Protein C against Viral Mimetic Poly(I:C)-Induced Inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofeng Cai,Sumith R Panicker,Indranil Biswas,Hemant Giri,Alireza R Rezaie

Blood cells, molecules & diseases 84:102459 PubMed32559654

2020

Hypoxia induced up-regulation of tissue factor is mediated through extracellular RNA activated Toll-like receptor 3-activated protein 1 signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Saumya Bhagat,Indranil Biswas,Rehan Ahmed,Gausal A Khan

Infection and immunity 86: PubMed29311246

2018

Candida albicans β-Glucan-Containing Particles Increase HO-1 Expression in Oral Keratinocytes via a Reactive Oxygen Species/p38 Mitogen-Activated Protein Kinase/Nrf2 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yoko Ishida,Kouji Ohta,Takako Naruse,Hiroki Kato,Akiko Fukui,Hideo Shigeishi,Hiromi Nishi,Kei Tobiume,Masaaki Takechi

European journal of immunology 45:3158-73 PubMed26350442

2015

Extracellular RNA facilitates hypoxia-induced leukocyte adhesion and infiltration in the lung through TLR3-IFN-γ-STAT1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Indranil Biswas,Bandana Singh,Manish Sharma,Paban K Agrawala,Gausal A Khan

PloS one 10:e0138041 PubMed26376485

2015

Characteristics of Human Turbinate-Derived Mesenchymal Stem Cells Are Not Affected by Allergic Condition of Donor.

Applications

Unspecified application

Species

Unspecified reactive species

Se Hwan Hwang,Hye Kyung Cho,Sang Hi Park,WeonSun Lee,Hee Jin Lee,Dong Chang Lee,Sun Hwa Park,Mi Hyun Lim,Sang A Back,Byeong Gon Yun,Dong Il Sun,Jun Myung Kang,Sung Won Kim

BMC cancer 15:245 PubMed25884709

2015

TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis.

Applications

IHC

Species

Unspecified reactive species

Ming-Ming Yuan,Yu-Yin Xu,Li Chen,Xing-Yu Li,Jing Qin,Ying Shen

PloS one 9:e101558 PubMed25004159

2014

Toll like receptor 3 & 4 responses of human turbinate derived mesenchymal stem cells: stimulation by double stranded RNA and lipopolysaccharide.

Applications

Flow Cyt

Species

Human

Se Hwan Hwang,Hye Kyung Cho,Sang Hi Park,WeonSun Lee,Hee Jin Lee,Dong Chang Lee,Jeong Hoon Oh,Sun Hwa Park,Tai-Gyu Kim,Hyun-Jung Sohn,Jun Myung Kang,Sung Won Kim

Scandinavian journal of clinical and laboratory investigation 71:641-6 PubMed22023039

2011

Toll like receptor 3 expression as a novel predictor of response to treatment in chronic hepatitis C virus patients.

Applications

IHC-P

Species

Human

Doaa I Hashad,Perihan E Salem,Dina M Abdallah

Molecular immunology 47:883-93 PubMed19914718

2009

Scavenger receptor A1 is required for sensing HCMV by endosomal TLR-3/-9 in monocytic THP-1 cells.

Applications

Species

Unspecified reactive species

Kok-Hooi Yew,Bonnie Carsten,Christopher Harrison

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-TLR3 抗体 [TLR3.7]

Anti-TLR3 antibody [TLR3.7]

Flow Cytometry (Intracellular) - Anti-TLR3 antibody [TLR3.7] (AB12085)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (14)

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Abcam product promise