Anti-TLR2 抗体 [EPR2078Y] (ab68159)
![Western blot - Anti-TLR2 antibody [EPR2078Y] (ab68159)](https://www.abcam.co.jp/ps/products/68/ab68159/Images/ab68159-82370-anti-tlr2-antibody-epr2078y-western-blot.jpg "Western blot - Anti-TLR2 antibody [EPR2078Y] (ab68159)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR2078Y] to TLR2
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-TLR2 antibody [EPR2078Y]
TLR2 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR2078Y] to TLR2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,IHC-P or IP -
種交差性
交差種: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ･コントロール
- THP-1 cell lysate
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 50% Tissue culture supernatant -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR2078Y -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab68159の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
| 特記事項 |
|---|
追加情報
ICC: 1/250 - 1/500.
WB: 1/500 - 1/2000. Detects a band of approximately 90 kDa (predicted molecular weight: 90 kDa).
Is unsuitable for Flow Cyt, IHC-P or IP.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/2000. Detects a band of approximately 90 kDa (predicted molecular weight: 90 kDa).
Is unsuitable for Flow Cyt, IHC-P or IP.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. -
組織特異性
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. -
配列類似性
Belongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain. -
翻訳後修飾
Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 7097 Human
- Omim: 603028 Human
- SwissProt: O60603 Human
- Unigene: 519033 Human
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別名
- CD282 antibody
- CD282 antigen antibody
- TIL 4 antibody
see all
画像
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Western blot - Anti-TLR2 antibody [EPR2078Y] (ab68159)Anti-TLR2 antibody [EPR2078Y] (ab68159) at 1/500 dilution + THP-1 cell lysate at 10 µg
Secondary
HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 90 kDa
Observed band size: 90 kDa -
![Anti-TLR2 antibody [EPR2078Y] (ab68159)](https://www.abcam.co.jp/ps/products/68/ab68159/Images/ab68159-2-benefits-of-recombinant-antibodies.png)
Anti-TLR2 antibody [EPR2078Y] (ab68159)
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab68159 は 4 報の論文で使用されています。
- Koch F et al. Mild heat stress-induced adaptive immune response in blood mononuclear cells and leukocytes from mesenteric lymph nodes of primiparous lactating Holstein cows. J Dairy Sci 106:3008-3022 (2023). PubMed: 36894431
- Niu X et al. Serum amyloid A 1 induces suppressive neutrophils through the Toll-like receptor 2-mediated signaling pathway to promote progression of breast cancer. Cancer Sci 113:1140-1153 (2022). PubMed: 35102665
- Ding J et al. Role of PIM2 in acute lung injury induced by sepsis. Exp Ther Med 24:543 (2022). PubMed: 35978927
- Al-Sadi R et al. Bifidobacterium bifidum Enhances the Intestinal Epithelial Tight Junction Barrier and Protects against Intestinal Inflammation by Targeting the Toll-like Receptor-2 Pathway in an NF-κB-Independent Manner. Int J Mol Sci 22:N/A (2021). PubMed: 34360835