JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB21273

Anti-TLR10 抗体

Anti-TLR10 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal TLR10 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TLR10.

別名を表示する

CD290, UNQ315/PRO358, TLR10, Toll-like receptor 10

1 Images
Western blot - Anti-TLR10 antibody (AB21273)
  • WB

Unknown

Western blot - Anti-TLR10 antibody (AB21273)

Lane 1:

Western blot - Anti-TLR10 antibody (ab21273) at 0.5 µg/mL

Lane 2:

Western blot - Anti-TLR10 antibody (ab21273) at 1 µg/mL

All lanes:

Human lymph node cell lysates

Predicted band size: 95 kDa

Observed band size: 75 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human TLR10. The exact immunogen used to generate this antibody is proprietary information.

Q9BXR5

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification
精製に関する特記事項
Ion exchange chromatography.
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TLR10 also known as Toll-like receptor 10 is part of the Toll-like receptor family and its molecular weight is approximately 90 kDa. TLR10 is expressed in various tissues more particularly in immune cells such as B cells monocytes and dendritic cells. It plays a mechanical role in recognizing pathogen-associated molecular patterns which is important for the activation of innate immune responses.
Biological function summary

TLR10 is involved in mediating immune system responses against pathogens. While it has shown similarities with other toll-like receptors its exact ligands and signaling pathways are still under investigation. TLR10 may exist as part of a receptor complex which helps in transmitting signals from pathogens to activate appropriate immune responses. This receptor's involvement suggests it has an important role in innate immunity and inflammation regulation.

Pathways

Several scientific studies have indicated that TLR10 participates in the innate immune signaling pathways. It potentially interacts with components of the TLR signaling pathway similar to other members of the TLR family like TLR2 and TLR4. Through the MyD88-dependent signaling pathway TLR10 may activate transcription factors such as NF-kB which leads to the production of pro-inflammatory cytokines. These interactions suggest TLR10 is important for modulating immune responses.

Researchers have linked TLR10 to inflammatory conditions and immune system disorders. Current research shows that altered expression or function of TLR10 could relate to autoimmune diseases like rheumatoid arthritis through its influence on immune cell activation. Additionally TLR10 has connections to certain cancers as inflammation pathways can also contribute to cancer development. TLR10 in conjunction with other Toll-like receptors may influence disease progression and offers potential as a therapeutic target.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
See full target information TLR10
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine reports 13:3265-72 PubMed26936681

2016

Downregulation of VEGF and upregulation of TL1A expression induce HUVEC apoptosis in response to high glucose stimuli.

Applications

Unspecified application

Species

Unspecified reactive species

Miao Yu,Guihua Lu,Xun Zhu,Zhibin Huang,Chong Feng,Rong Fang,Yesong Wang,Xiuren Gao
View all publications
style
left-column
style
left-column
style
right-column

代替製品

Primary Antibodies

AB113446

Anti-TLR10 antibody [3C10C5]

  • 0
  • 0
Primary Antibodies

AB53631

Anti-TLR10 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TLR10 antibody (AB53631)

  • 0
  • 0
Primary Antibodies

AB228511

Anti-TLR10 antibody [ABM3C85]

Western blot - Anti-TLR10 antibody [ABM3C85] (AB228511)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB211012

Anti-TLR9 antibody [EPR21735]

KO Validated|RabMAb|Recombinant

Western blot - Anti-TLR9 antibody [EPR21735] (AB211012)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB180610

Anti-TLR8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-TLR8 antibody (AB180610)

  • 5
  • 5
Primary Antibodies

AB68158

Anti-TIL/TLR1 antibody [EPR2075]

RabMAb|Recombinant

Flow Cytometry - Anti-TIL/TLR1 antibody [EPR2075] (AB68158)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com