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AB231176

Anti-TIMP2 抗体

Anti-TIMP2 antibody

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(1 Publication)

Rabbit Polyclonal TIMP2 antibody. Suitable for WB and reacts with Recombinant fragment - Horse, Rat, Cow samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Horse TIMP2 aa 1 to C-terminus.

別名を表示する

Timp-2, Timp2, Metalloproteinase inhibitor 2, Tissue inhibitor of metalloproteinases 2, TIMP-2

4 Images
Western blot - Anti-TIMP2 antibody (AB231176)
  • WB

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Rat placenta lysate

Predicted band size: 24 kDa

false

Western blot - Anti-TIMP2 antibody (AB231176)
  • WB

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Recombinant horse TIMP2 protein

Predicted band size: 24 kDa

false

Western blot - Anti-TIMP2 antibody (AB231176)
  • WB

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Cow cerebrum lysate

Predicted band size: 24 kDa

false

Western blot - Anti-TIMP2 antibody (AB231176)
  • WB

Supplier Data

Western blot - Anti-TIMP2 antibody (AB231176)

All lanes:

Western blot - Anti-TIMP2 antibody (ab231176) at 2 µg/mL

All lanes:

Cow kidney lysate

Predicted band size: 24 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat, Cow

アプリケーション

WB

applications

免疫原

Recombinant Fragment Protein within Horse TIMP2 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O77717

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代替製品

Primary Antibodies

AB180630

Anti-TIMP2 antibody

Western blot - Anti-TIMP2 antibody (AB180630)

  • 5
  • 1
Primary Antibodies

AB230511

Anti-TIMP2 antibody [F27P3A4]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP2 antibody [F27P3A4] (AB230511)

  • 0
  • 0
Primary Antibodies

AB1828

Anti-TIMP2 antibody [3A4]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIMP2 antibody [3A4] (AB1828)

  • 4
  • 7

組合せ製品

Assay Kits

AB270213

Human TIMP2 ELISA Kit

Recombinant|SimpleStep

ELISA - Human TIMP2 ELISA Kit (AB270213)

  • 5
  • 1
Primary Antibodies

AB92536

Anti-MMP2 antibody [EPR1184]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-MMP2 antibody [EPR1184] (AB92536)

  • 4
  • 6
Primary Antibodies

AB47637

Anti-TIM 4 antibody

Western blot - Anti-TIM 4 antibody (AB47637)

  • 0
  • 0
Primary Antibodies

AB52903

Anti-SMAD3 (pS423/425) + SMAD5 (pS463/465) + SMAD1 (pS463/465) + SMAD2 (pS465/467) antibody [EP823Y]

20ul selling size|Recombinant|Advanced Validation|RabMAb

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMAD3 (pS423/425) + SMAD5 (pS463/465 ) + SMAD1 (pS463/465) + SMAD2 (pS465/467) antibody [EP823Y] (AB52903)

  • 4
  • 21
Primary Antibodies

AB283575

Anti-MMP9 antibody [RM1020]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Trial Size

Flow Cytometry (Intracellular) - Anti-MMP9 antibody [RM1020] (AB283575)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Recombinant fragment - Horse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab231176 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TIMP2 also known as Tissue Inhibitor of Metalloproteinases 2 mechanistically inhibits the activity of matrix metalloproteinases (MMPs). It binds to MMPs regulating the extracellular matrix's remodeling. The protein has a molecular mass of around 21 kDa. TIMP2 is expressed in various tissues including the brain liver and kidneys where it maintains a balance between matrix degradation and production.
Biological function summary

TIMP2 plays a significant role in tissue maintenance and repair by controlling extracellular matrix turnover. It forms complexes with MMPs such as MMP-2 inhibiting their proteolytic activities. The protein is also involved in cell proliferation and differentiation affecting processes like angiogenesis and wound healing. Its regulatory function aids in maintaining tissue homeostasis and preventing excessive matrix breakdown.

Pathways

TIMP2 is integral to the matrix metalloproteinase pathway and the regulation of endothelial cell migration. The protein interacts closely with other MMPs influencing their activation and modulation. Through these pathways TIMP2 holds an important position in cellular migration and signaling ensuring precise matrix remodeling in response to physiological needs.

TIMP2 has significant links with cancer and fibrosis. Dysregulation of TIMP2 expression or its imbalance with MMPs can contribute to tumor progression and metastasis due to uncontrolled matrix degradation. Additionally abnormal TIMP2 levels associate with fibrotic diseases where excessive tissue deposition occurs. TIMP2's interaction with proteins like MMP-9 and MMP-2 highlights its involvement in these pathological conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
See full target information Timp2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Integrative cancer therapies 24:15347354251375464 PubMed40958203

2025

Sennoside A Modulates the Ferroptosis and Immune Evasion of Oral Squamous Cell Carcinoma Cells Through Inhibiting the NF-κB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaying Huo,Jianhua Qi,Qixuan Ren
View all publications
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