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AB168649

Anti-TIM44 抗体

Anti-TIM44 antibody

2

(2 Reviews)

|

(1 Publication)

Mouse Polyclonal TIM44 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TIMM44.

別名を表示する

MIMT44, TIM44, TIMM44, Mitochondrial import inner membrane translocase subunit TIM44

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human TIMM44.

O43615

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代替製品

Primary Antibodies

AB232592

Anti-TIM44 antibody [EPR16821-26] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-TIM44 antibody [EPR16821-26] - BSA and Azide free (AB232592)

  • 0
  • 0
Primary Antibodies

AB244466

Anti-TIM44 antibody

Immunocytochemistry/ Immunofluorescence - Anti-TIM44 antibody (AB244466)

  • 0
  • 0
Primary Antibodies

AB201453

Anti-TIM44 antibody [EPR16821-26]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-TIM44 antibody [EPR16821-26] (AB201453)

  • 4
  • 1
Primary Antibodies

AB194829

Anti-TIM44 antibody [EPR16821]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TIM44 antibody [EPR16821] (AB194829)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
Primary Antibodies

AB109436

Anti-TIM50 antibody [EPR5785]

RabMAb|Recombinant

Western blot - Anti-TIM50 antibody [EPR5785] (AB109436)

  • 5
  • 2
Primary Antibodies

AB57523

Anti-TOMM22/TOM22 antibody [4G4]

Immunocytochemistry/ Immunofluorescence - Anti-TOMM22/TOM22 antibody [4G4] (AB57523)

  • 0
  • 0
Primary Antibodies

AB186735

Anti-TOMM20 antibody [EPR15581-54] - Mitochondrial Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-TOMM20 antibody [EPR15581-54] - Mitochondrial Marker (AB186735)

  • 5
  • 16
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TIM44 also known as translocase of inner mitochondrial membrane 44 serves an important role in mitochondrial protein import mechanisms. The protein weighs approximately 44 kDa and localizes in the inner mitochondrial membrane. TIM44 works as an essential part of the mitochondrial inner membrane presequence translocase complex where it assists in guiding proteins into the mitochondrial matrix. Expression of TIM44 is observed mainly in tissues with high energetic demands such as muscle and liver.
Biological function summary

TIM44 functions in conjunction with other components of the TIM23 complex which includes proteins like TIM23 and TIM17. The main role of TIM44 involves connecting the translocase complex to mitochondrial heat shock protein 70 (mtHsp70) facilitating ATP-dependent translocation of polypeptides. This process supports the import of precursor proteins synthesized in the cytosol into the mitochondria ensuring proper mitochondrial function and energy production.

Pathways

TIM44 influences the mitochondrial protein import pathway and the maintenance of mitochondrial function. As part of the protein import machinery it connects closely to the chaperone-mediated folding pathway aided by mtHsp70. The TIM23 complex participates in the translocation of proteins with mitochondrial targeting sequences linking TIM44 to pathways essential for mitochondrial biogenesis and function.

Dysfunction in the TIM44 protein associates with mitochondrial disorders including those impacting oxidative phosphorylation capacity. Mutations or deficiencies in TIM44 have connections to disorders such as mitochondrial myopathy. Relation to other proteins such as mtHsp70 and components of oxidative phosphorylation emphasizes the role of TIM44 in cellular energy homeostasis and highlights its importance in maintaining mitochondrial health.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity).
See full target information TIMM44
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 14:403-410 PubMed26774479

2016

EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter.

Applications

Unspecified application

Species

Unspecified reactive species

Horia Vais,Karthik Mallilankaraman,Don-On Daniel Mak,Henry Hoff,Riley Payne,Jessica E Tanis,J Kevin Foskett
View all publications
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Abcam product promise

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