Anti-TICAM2 抗体 (ab17221)
Key features and details
- Rabbit polyclonal to TICAM2
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-TICAM2 antibody
TICAM2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TICAM2 -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide (Human) (C terminal).
-
ポジティブ・コントロール
- PC3 whole cell lysate.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
-
精製度
Ion Exchange Chromatography -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab17221の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ICC/IF |
Use a concentration of 10 µg/ml.
|
|
WB |
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 24 kDa.
|
特記事項 |
---|
ICC/IF
Use a concentration of 10 µg/ml. |
WB
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 24 kDa. |
ターゲット情報
-
機能
Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1. -
組織特異性
Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas. -
配列類似性
Contains 1 TIR domain. -
ドメイン
The TIR domain mediates the interaction with TRAF6. -
翻訳後修飾
Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling. -
細胞内局在
Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. - Information by UniProt
-
参照データベース
- Entrez Gene: 100302736 Human
- Entrez Gene: 353376 Human
- Omim: 608321 Human
- SwissProt: Q86XR7 Human
- Unigene: 709120 Human
-
別名
- Putative NF-kappa-B-activating protein 502 antibody
- TCAM2_HUMAN antibody
- TICAM-2 antibody
see all
画像
-
Western Blot of PC-3 cell lysate labeling TICAM2 with Anti-TICAM2 antibody (ab17221) at 1µg/ml.
-
Anti-TICAM2 antibody (ab17221) at 1 µg/ml + PC-3 cell lysate
Predicted band size: 24 kDa
Western blot using ab17221 at 1µ g/ml on PC-3 cell lysate. -
ab17221 at 10µg/ml staining TICAM2 in Raji cells by ICC/IF
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (2)
ab17221 は 2 報の論文で使用されています。
- Alsaqer SF et al. Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Oncotarget 8:73372-73386 (2017). PubMed: 29088714
- Endo Y et al. Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1ß and TRIF/IRF3. PLoS One 9:e98517 (2014). WB ; Human . PubMed: 24870145