AB12500

Anti-Thyroid Peroxidase/TPO 抗体 [MoAb47]

Name: Anti-Thyroid Peroxidase/TPO 抗体 [MoAb47] (ab12500) | Abcam
Brand: Abcam Limited
SKU: AB12500
Price: 49000 JPY
Availability: InStock

Anti-Thyroid Peroxidase/TPO antibody [MoAb47]

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(3 Publications)

Mouse Monoclonal Thyroid Peroxidase/TPO antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human Thyroid peroxidase.

別名を表示する

Thyroid peroxidase, TPO

1 Images

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Peroxidase/TPO antibody [MoAb47] (AB12500)

Formalin-fixed, paraffin-embeded human thyroid tissue stained for Thyroid Peroxidase/TPO using ab12500 at 1/10 dilution in immunohistochemical analysis.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

MoAb47

アイソタイプ

IgG1

キャリアフリー

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Native Full Length Protein corresponding to Human Thyroid peroxidase.

P07202

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/25", "IHCP-species-notes": "<p>Primary incubation for 30 min at room temperature.</p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Tissue culture supernatant

バッファー組成

pH: 7.3 - 7.5 Preservative: 0.05% Sodium azide Constituents: Tissue culture supernatant

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Thyroid Peroxidase (TPO) also known as thyroperoxidase is an enzyme with a molecular mass of around 105 kDa. It is expressed in the thyroid gland's follicular cells. TPO plays a mechanical role in the synthesis of thyroid hormones by catalyzing iodination and coupling reactions needed to produce triiodothyronine (T3) and thyroxine (T4). These hormones are essential for regulating metabolism growth and development. The activity of TPO is an important step in thyroid hormone production.

Biological function summary

TPO participates in the thyroid's hormone biosynthesis pathway. It forms a part of the multi-enzyme complex that includes thyroglobulin and iodide. The enzyme facilitates the iodination of tyrosine residues on thyroglobulin and the coupling of iodotyrosines important for creating active thyroid hormones. TPO's enzymatic function is important for maintaining appropriate levels of circulating T3 and T4 impacting various physiological processes in the body.

Pathways

TPO contributes to the thyroid hormone synthesis pathway which is a critical pathway for metabolic regulation. It works in close association with other proteins such as thyroglobulin and sodium/iodide symporter (NIS) to ensure efficient thyroid hormone production. TPO's involvement in these pathways indicates its importance in the endocrine system's normal function and homeostasis.

TPO is often associated with autoimmune thyroid diseases like Hashimoto's thyroiditis and Graves' disease. High TPO antibodies such as anti-TPO antibodies are commonly detected in these conditions indicating an autoimmune response against the thyroid. The presence of high anti-thyroid peroxidase antibodies can lead to the destruction of thyroid tissue often resulting in hypothyroidism. TPO's connection to these diseases highlights its role in autoimmune conditions affecting thyroid function.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

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ターゲットの情報

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

See full target information Thyroid peroxidase

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of cancer 134:1706-14 PubMed24114667

2013

Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?

Applications

Unspecified application

Species

Unspecified reactive species

I Muller,C Giani,L Zhang,F A Grennan-Jones,E Fiore,V Belardi,V Rosellini,N Funel,D Campani,E Giustarini,M D Lewis,A D Bakhsh,M Roncella,M Ghilli,P Vitti,C M Dayan,M E Ludgate

Biochemical and biophysical research communications 392:22-8 PubMed20043873

2010

Muscle cells enhance resistance to pro-inflammatory cytokine-induced cartilage destruction.

Applications

Unspecified application

Species

Unspecified reactive species

Dana M Cairns,Tomoya Uchimura,Heenam Kwon,Philip G Lee,Christopher R Seufert,Elizabeth Matzkin,Li Zeng

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 28:529-36 PubMed19813241

2009

The role of muscle cells in regulating cartilage matrix production.

Applications

Unspecified application

Species

Unspecified reactive species

Dana M Cairns,Philip G Lee,Tomoya Uchimura,Christopher R Seufert,Heenam Kwon,Li Zeng

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Thyroid Peroxidase/TPO 抗体 [MoAb47]

Anti-Thyroid Peroxidase/TPO antibody [MoAb47]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Peroxidase/TPO antibody [MoAb47] (AB12500)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

短期保存温度

長期保存温度

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

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Abcam product promise