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AB5622

Anti-Thyroid Hormone Receptor beta 抗体

Anti-Thyroid Hormone Receptor beta antibody

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(28 Publications)

Rabbit Polyclonal Thyroid Hormone Receptor beta antibody. Suitable for IHC-P and reacts with Rat, Human samples. Cited in 28 publications. Immunogen corresponding to Synthetic Peptide within Human THRB aa 50-100.

別名を表示する

ERBA2, NR1A2, THR1, THRB, Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody (AB5622)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody (AB5622)

ab5622 labelling Thyroid Hormaone Receptor beta in the nucleus of Human thyroid tissue (right) compared with a negative control (left). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0) microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature. Tissue sections were incubated with the primary antibody (1 : 200 in 3% BSA-PBS) overnight at 4°C. A HRP-conjugated anti-rabbit IgG was used as the secondary antibody, followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody (AB5622)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody (AB5622)

ab5622 staining Thyroid Hormone Receptor in Human colon tissue sections (right) compared to negative control (left) by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde and blocked with 3% H2O2-methanol for 15 minutes at room temperature; antigen retrieval was by heat mediation in a citrate buffer. Samples were incubated with primary antibody (1/20) for 1 hour at 37°C. A HRP-conjugated secondary antibody was used for detection.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody (AB5622)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody (AB5622)

ab5622 labelling Thyroid Hormaone Receptor beta in the nucleus of Rat thyroid tissue (right) compared with a negative control (left). To expose target proteins, antigen retrieval method was performed using 10mM sodium citrate (pH 6.0) microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature. Tissue sections were incubated with the primary antibody (1 : 200 in 3% BSA-PBS) overnight at 4°C. A HRP-conjugated anti-rabbit IgG was used as the secondary antibody, followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat, Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human THRB aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

P10828

特異性

This antibody does not detect TR alpha-1 or TRv alpha-2.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100.00000 - 1/500.00000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100.00000 - 1/500.00000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製度
Whole antiserum
バッファー組成
Preservative: 0.05% Sodium azide Constituents: 99% PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Thyroid Hormone Receptor beta (THRB) also known as c-erbA-2 and NR1A2 is a nuclear hormone receptor and transcription factor weighing approximately 55 kDa. THRB binds thyroid hormones and plays a central role in moderating gene expression. Expression of this receptor occurs in various tissues with notable presence in the liver brain and heart. As a transcription factor it influences the transcription of specific target genes upon binding to thyroid hormones primarily thyroxine (T4) and triiodothyronine (T3).
Biological function summary

This receptor regulates critical metabolic processes and plays a role in development. THRB functions as part of a larger receptor complex partnering with retinoid X receptor (RXR) to form a heterodimer. This dimer binds to thyroid hormone response elements (TREs) on DNA modulating the expression of genes involved in metabolism thermogenesis and development of the central nervous system. The receptor's activity impacts many key physiological functions ensuring proper growth and metabolic balance.

Pathways

THRB engages significantly in the thyroid hormone signaling pathway and the lipid degradation pathway. It interacts with proteins like the aforementioned RXR in promoting transcriptional activities. In its regulatory capacity THRB helps facilitate lipid metabolism cholesterol homeostasis and energy management. As part of the thyroid hormone signaling pathway it controls numerous genes aligning with proteins like thyroid peroxidase (TPO) which in turn affect hormone synthesis.

Mutations or malfunctions in THRB relate to conditions such as resistance to thyroid hormone (RTH) and medullary thyroid carcinoma. In RTH inappropriate THRB activity results in altered thyroid hormone action and impaired feedback mechanism. This connects to disrupted signaling involving proteins like thyroglobulin. In medullary thyroid carcinoma THRB alterations can influence tumor progression demonstrating its impact on cellular regulatory mechanisms. Understanding THRB's involvement in these disorders aids in diagnosing and developing targeted therapeutic approaches.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
See full target information THRB
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文献 (28)

Recent publications for all applications. Explore the full list and refine your search

Reproductive biology and endocrinology : RB&E 21:108 PubMed37968664

2023

Thyroid hormone transport and metabolism are disturbed in the placental villi of miscarriage.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Yu,Xinghao Feng,Zhongshan Lin,Xuan Li,Shiyue Su,Huiru Cheng,Yuanyuan Yang,Zhaolian Wei

Cell death & disease 14:474 PubMed37500624

2023

Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterol.

Applications

Unspecified application

Species

Unspecified reactive species

Joo-Ok Min,Hoang-Anh Ho,Wonjae Lee,Byung Chul Jung,Sung Jun Park,Seokjoong Kim,Seung-Jae Lee

CNS neuroscience & therapeutics 29:129-139 PubMed36341958

2022

Selective brain hypothermia attenuates focal cerebral ischemic injury and improves long-term neurological outcome in aged female mice.

Applications

Unspecified application

Species

Unspecified reactive species

Liqiang Liu,Jia Liu,Ming Li,Junxuan Lyu,Wei Su,Shejun Feng,Xunming Ji

Annals of neurology 92:45-60 PubMed35467038

2022

A Role for Insulin-like Growth Factor 1 in the Generation of Epileptic Spasms in a murine model.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos J Ballester-Rosado,John T Le,Trang T Lam,Carrie A Mohila,Sandi Lam,Anne E Anderson,James D Frost,John W Swann

Biochemical and biophysical research communications 576:15-21 PubMed34474245

2021

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

Applications

Unspecified application

Species

Unspecified reactive species

Wesley Wang,Dolena Ledee

Frontiers in cell and developmental biology 9:636802 PubMed33869182

2021

Thyroid Hormone-Regulated Expression of Period2 Promotes Liver Urate Production.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoting Chen,Mian Wu,Nan Liang,Junxi Lu,Shen Qu,Haibing Chen

Cell reports 34:108780 PubMed33626347

2021

Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Hanseul Kweon,Won Beom Jung,Geun Ho Im,Jia Ryoo,Joon-Hyuk Lee,Hogyeong Do,Yeonsoo Choi,You-Hyang Song,Hwajin Jung,Haram Park,Lily R Qiu,Jacob Ellegood,Hyun-Ji Shim,Esther Yang,Hyun Kim,Jason P Lerch,Seung-Hee Lee,Won-Suk Chung,Daesoo Kim,Seong-Gi Kim,Eunjoon Kim

Aging and disease 12:72-92 PubMed33532129

2021

Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Suning Ping,Xuecheng Qiu,Michele Kyle,Li-Ru Zhao

Stem cell research & therapy 11:504 PubMed33246498

2020

Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes.

Applications

Unspecified application

Species

Unspecified reactive species

Edit Hathy,Eszter Szabó,Nóra Varga,Zsuzsa Erdei,Csongor Tordai,Boróka Czehlár,Máté Baradits,Bálint Jezsó,Júlia Koller,László Nagy,Mária Judit Molnár,László Homolya,Zsófia Nemoda,Ágota Apáti,János M Réthelyi

The Journal of neuroscience : the official journal 40:9564-9575 PubMed33158959

2020

Postsynaptic Serine Racemase Regulates NMDA Receptor Function.

Applications

Unspecified application

Species

Unspecified reactive species

Jonathan M Wong,Oluwarotimi O Folorunso,Eden V Barragan,Cristina Berciu,Theresa L Harvey,Joseph T Coyle,Darrick T Balu,John A Gray
View all publications
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