Anti-Thyroglobulin 抗体 [5F9] (ab1984)
Key features and details
- Mouse monoclonal [5F9] to Thyroglobulin
- Suitable for: Sandwich ELISA, EIA
- Reacts with: Cow, Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-Thyroglobulin antibody [5F9]
Thyroglobulin 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [5F9] to Thyroglobulin -
由来種
Mouse -
特異性
This antibody does not interfere with anti-thyroglobulin autoantibodies. -
アプリケーション
適用あり: Sandwich ELISA, EIAmore details -
種交差性
交差種: Cow, Human -
免疫原
Full length native protein (purified) corresponding to Thyroglobulin.
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特記事項
Concentration varies from lot to lot and can be provided on request.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.1% Sodium azide -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
5F9 -
ミエローマ
Sp2/0 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab1984の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Sandwich ELISA |
Use at an assay dependent concentration.
|
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| EIA |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
Sandwich ELISA
Use at an assay dependent concentration. |
|
EIA
Use at an assay dependent concentration. |
ターゲット情報
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機能
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). -
組織特異性
Thyroid gland specific. -
関連疾患
Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. -
配列類似性
Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains. -
翻訳後修飾
Sulfated tyrosines are desulfated during iodination. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 280706 Cow
- Entrez Gene: 7038 Human
- Omim: 188450 Human
- SwissProt: P01267 Cow
- SwissProt: P01266 Human
- Unigene: 654591 Human
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別名
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
see all
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab1984 は論文での使用が確認できていません。