Anti-Thromboxane synthase 抗体 (ab39362)
Key features and details
- Rabbit polyclonal to Thromboxane synthase
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Thromboxane synthase antibody
Thromboxane synthase 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Thromboxane synthase -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Cynomolgus monkey
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免疫原
Synthetic peptide:
TNPDCQEKLLREVDVFKEK
, corresponding to amino acids 359/377 of Human Thromboxane synthase -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituents: 0.1% BSA, 50% Glycerol, Tris buffered saline -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
ab39362 is an affinity purified IgG -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab39362の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500. Detects a band of approximately 54 kDa (predicted molecular weight: 61 kDa).
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| 特記事項 |
|---|
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WB
1/500. Detects a band of approximately 54 kDa (predicted molecular weight: 61 kDa). |
ターゲット情報
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組織特異性
Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. -
関連疾患
Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis. -
配列類似性
Belongs to the cytochrome P450 family. -
細胞内局在
Endoplasmic reticulum membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6916 Human
- Omim: 274180 Human
- SwissProt: Q2PG45 Cynomolgus monkey
- SwissProt: P24557 Human
- Unigene: 520757 Human
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別名
- BDPLT14 antibody
- CYP5 antibody
- CYP5A1 antibody
see all
画像
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Western blot - Anti-Thromboxane synthase antibody (ab39362)All lanes : Anti-Thromboxane synthase antibody (ab39362) at 1 µg/ml
Lane 1 : Human spleen tissue lysate - total protein (ab29699)
Lane 2 : WI38 (Human lung fibroblast cell line) Whole Cell Lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 61 kDa
Observed band size: 54 kDa why is the actual band size different from the predicted?
Additional bands at: 21 kDa, 36 kDa. We are unsure as to the identity of these extra bands.
Exposure time: 8 minutes
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab39362 は 9 報の論文で使用されています。
- Pai CH et al. Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy. PLoS One 11:e0151617 (2016). IHC . PubMed: 26974824
- Walker MA et al. Vasoactive enzymes and blood flow responses to passive and active exercise in peripheral arterial disease. Atherosclerosis 246:98-105 (2016). PubMed: 26771386
- Font-Nieves M et al. Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes. J Biol Chem 287:6454-68 (2012). WB ; Mouse . PubMed: 22219191
- Chu LM et al. Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. Am J Physiol Heart Circ Physiol 302:H479-88 (2012). WB ; Pig . PubMed: 22037194
- Feng J et al. Thromboxane-induced contractile response of human coronary arterioles is diminished after cardioplegic arrest. Ann Thorac Surg 92:829-36 (2011). WB ; Human . PubMed: 21871266
- Carter PR et al. Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis. Inflamm Res 60:87-92 (2011). IHC-Fr ; Mouse . PubMed: 20694740
- Shoeb M et al. Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. Free Radic Biol Med 51:1686-96 (2011). WB ; Mouse . PubMed: 21856412
- Hansen AH et al. Exercise training alters the balance between vasoactive compounds in skeletal muscle of individuals with essential hypertension. Hypertension 58:943-9 (2011). PubMed: 21896936
- Wright WS et al. Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina. Exp Eye Res 89:532-7 (2009). IHC-P ; Mouse, Rat . PubMed: 19523949