Anti-Thromboxane synthase 抗体 (ab187176)
Key features and details
- Rabbit polyclonal to Thromboxane synthase
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Thromboxane synthase antibody
Thromboxane synthase 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Thromboxane synthase -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant fragment corresponding to Human Thromboxane synthase aa 354-533 (C terminal).
Database link: P24557 -
ポジティブ･コントロール
- A549, HT-29, U937 and H460 cell extracts.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.30
Preservative: 0.09% Sodium azide
Constituents: 49.91% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab187176の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/2000. Predicted molecular weight: 61 kDa.
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| IHC-P |
1/50 - 1/200.
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| 特記事項 |
|---|
|
WB
1/500 - 1/2000. Predicted molecular weight: 61 kDa. |
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IHC-P
1/50 - 1/200. |
ターゲット情報
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組織特異性
Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. -
関連疾患
Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis. -
配列類似性
Belongs to the cytochrome P450 family. -
細胞内局在
Endoplasmic reticulum membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6916 Human
- Entrez Gene: 21391 Mouse
- Omim: 274180 Human
- SwissProt: P24557 Human
- SwissProt: P36423 Mouse
- Unigene: 520757 Human
- Unigene: 4054 Mouse
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別名
- BDPLT14 antibody
- CYP5 antibody
- CYP5A1 antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane synthase antibody (ab187176)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse lung tissue labelling Thromboxane synthase with ab187176 at 1/200. Magnification: 400x.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane synthase antibody (ab187176)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid cancer tissue labelling Thromboxane synthase with ab187176 at 1/200. Magnification: 400x. -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thromboxane synthase antibody (ab187176)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human endometrial cancer tissue labelling Thromboxane synthase with ab187176 at 1/200. Magnification: 400x. -
Western blot - Anti-Thromboxane synthase antibody (ab187176)All lanes : Anti-Thromboxane synthase antibody (ab187176) at 1/500 dilution
Lane 1 : A549 cell extract
Lane 2 : HT-29 cell extract
Lane 3 : U937 cell extract
Lane 4 : H460 cell extract
Predicted band size: 61 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab187176 は 2 報の論文で使用されています。
- Cianciaruso C et al. Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles. Cell Rep 27:3062-3080.e11 (2019). PubMed: 31167148
- Li H et al. Vascular Protection of TPE-CA on Hyperhomocysteinemia-induced Vascular Endothelial Dysfunction through AA Metabolism Modulated CYPs Pathway. Int J Biol Sci 15:2037-2050 (2019). PubMed: 31592228