AB78421

Anti-TGF beta Receptor III/TGFBR3 抗体 [MM0057-5G9]

Name: Anti-TGF beta Receptor III/TGFBR3 抗体 [MM0057-5G9] (ab78421) | Abcam
Brand: Abcam Limited
SKU: AB78421
Price: 74000 JPY
Availability: InStock

Anti-TGF beta Receptor III/TGFBR3 antibody [MM0057-5G9]

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(8 Publications)

Mouse Monoclonal TGF beta Receptor III/TGFBR3 antibody. Carrier free. Suitable for Flow Cyt, IHC-P and reacts with Human samples. Cited in 8 publications.

別名を表示する

Transforming growth factor beta receptor type 3, TGF-beta receptor type 3, TGFR-3, Betaglycan, Transforming growth factor beta receptor III, TGF-beta receptor type III, TGFBR3

2 Images

Flow Cytometry - Anti-TGF beta Receptor III/TGFBR3 antibody [MM0057-5G9] (AB78421)

Flow Cyt

Unknown

Flow Cytometry - Anti-TGF beta Receptor III/TGFBR3 antibody [MM0057-5G9] (AB78421)

Overlay histogram showing K562 cells stained with ab78421 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab78421, 1μg/1x10⁶ cells) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x10⁶ cells) used under the same conditions. Acquisition of >5,000 events was performed.

Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TGF beta Receptor III/TGFBR3 antibody [MM0057-5G9] (AB78421)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TGF beta Receptor III/TGFBR3 antibody [MM0057-5G9] (AB78421)

ab78421 at 1/100 dilution, staining TGF beta Receptor III/TGFBR3 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

MM0057-5G9

アイソタイプ

IgG1

キャリアフリー

Yes

交差種

Human

アプリケーション

Flow Cyt, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

This antibody was selected for its ability to detect TGF beta Receptor III/TGFBR3. No cross reactivity was found to TGF beta Receptor I and Receptor II.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1 µg for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

精製に関する特記事項

The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution inphosphate buffered saline (PBS).

バッファー組成

Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis (PubMed : 12958365, PubMed : 19416857). Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5 (PubMed : 18184661). Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking (PubMed : 19726563). Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin (PubMed : 22562249). By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B (PubMed : 19416857, PubMed : 19325136). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (By similarity). Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization (PubMed : 19416857). Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway (By similarity).. (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL.

See full target information TGFBR3

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文献 (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of biochemical and molecular toxicology 35:e22866 PubMed34369033

2021

SNHG5 protects chondrocytes in interleukin-1β-stimulated osteoarthritis via regulating miR-181a-5p/TGFBR3 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yue,Sun Zhibo,Liu Feng,Bai Yuanzhang,Wu Fei

Pflugers Archiv : European journal of physiology 473:287-311 PubMed33386991

2021

TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei.

Applications

Unspecified application

Species

Unspecified reactive species

Carolin Schilpp,Robin Lochbaum,Peter Braubach,Danny Jonigk,Manfred Frick,Paul Dietl,Oliver H Wittekindt

Cell reports 26:2667-2680.e7 PubMed30840889

2019

MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Liam Cornell,Seth A Wander,Tanvi Visal,Nikhil Wagle,Geoffrey I Shapiro

Medical science monitor : international medical jo 25:87-97 PubMed30606998

2019

Berberine, a Traditional Chinese Medicine, Reduces Inflammation in Adipose Tissue, Polarizes M2 Macrophages, and Increases Energy Expenditure in Mice Fed a High-Fat Diet.

Applications

Unspecified application

Species

Unspecified reactive species

Jiayu Lin,Qingyan Cai,Bo Liang,Lizhen Wu,Yong Zhuang,Yuanfang He,Wanrong Lin

Experimental and therapeutic medicine 15:4508-4514 PubMed29725386

2018

Downregulation of microRNA-193-3p inhibits the progression of intrahepatic cholangiocarcinoma cells by upregulating TGFBR3.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Long Han,Jia-Jun Yin,Jian-Jun Cong

Scientific reports 6:36520 PubMed27819283

2016

Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow.

Applications

Unspecified application

Species

Human

Kenji Yumoto,Matthew R Eber,Jingcheng Wang,Frank C Cackowski,Ann M Decker,Eunsohl Lee,Ana Rita Nobre,Julio A Aguirre-Ghiso,Younghun Jung,Russell S Taichman

Journal of immunology (Baltimore, Md. : 1950) 197:4344-4350 PubMed27793996

2016

Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yelena Bronevetsky,Trevor D Burt,Joseph M McCune

Proceedings of the National Academy of Sciences of 112:E957-65 PubMed25730867

2015

Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1.

Applications

Unspecified application

Species

Unspecified reactive species

Guangwei Liu,Yujing Bi,Lixiang Xue,Yan Zhang,Hui Yang,Xi Chen,Yun Lu,Zhengguo Zhang,Huanrong Liu,Xiao Wang,Ruoning Wang,Yiwei Chu,Ruifu Yang

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-TGF beta Receptor III/TGFBR3 抗体 [MM0057-5G9]

Anti-TGF beta Receptor III/TGFBR3 antibody [MM0057-5G9]

Flow Cytometry - Anti-TGF beta Receptor III/TGFBR3 antibody [MM0057-5G9] (AB78421)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TGF beta Receptor III/TGFBR3 antibody [MM0057-5G9] (AB78421)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

製品プロトコール

ターゲットの情報

文献 (8)

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Assay Kits

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Abcam product promise