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AB92279

Anti-TEA domain family member 2/ETF 抗体

Anti-TEA domain family member 2/ETF antibody

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(4 Publications)

Goat Polyclonal TEA domain family member 2/ETF antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TEAD2 aa 200-250.

別名を表示する

TEF4, TEAD2, Transcriptional enhancer factor TEF-4, TEA domain family member 2, TEAD-2

2 Images
Western blot - Anti-TEA domain family member 2/ETF antibody (AB92279)
  • WB

Unknown

Western blot - Anti-TEA domain family member 2/ETF antibody (AB92279)

Detected by chemiluminescence.

All lanes:

Western blot - Anti-TEA domain family member 2/ETF antibody (ab92279) at 1 µg/mL

All lanes:

Human colon lysate (35µg protein in RIPA buffer)

Predicted band size: 49 kDa

false

Western blot - Anti-TEA domain family member 2/ETF antibody (AB92279)
  • WB

Unknown

Western blot - Anti-TEA domain family member 2/ETF antibody (AB92279)

All lanes:

Western blot - Anti-TEA domain family member 2/ETF antibody (ab92279) at 1 µg/mL

All lanes:

Human ileum lysate in RIPA buffer at 35 µg

Predicted band size: 49 kDa

Observed band size: 50 kDa

true

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human TEAD2 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

Q15562

特異性

Not expected to cross-react with other TEA domain family proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
Purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
バッファー組成
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

TEA domain family member 2 (also known as ETF or TEAD2) is a transcription factor belonging to the TEAD protein family with a molecular mass around 47 kDa. TEAD2 plays an important mechanical role in regulating gene expression by binding to enhancer regions within the DNA. You will find TEAD2 predominantly expressed in tissues such as the brain heart and skeletal muscle. This expression pattern indicates its involvement in critical cellular activities.
Biological function summary

TEAD2 functions as a participant in the transcriptional activation of target genes by forming complexes with other cofactors such as YAP and TAZ. This complex formation facilitates the modulation of cell proliferation differentiation and apoptosis. TEAD2 activation leads to transcriptional regulation of genes promoting these cellular processes signifying its importance in maintaining tissue homeostasis and development.

Pathways

TEAD2 participates importantly in the Hippo signaling pathway which plays a role in organ size determination and tumor suppression. The TEAD2 pathway interaction occurs via its association with YAP and TAZ proteins which transmit signals from cell surface receptors to the nucleus. Additionally involvement in Wnt signaling connects TEAD2 to a network of proteins regulating embryonic development and adult tissue homeostasis further highlighting its pathway integration.

Dysregulation of TEAD2 activity has implications in oncological processes especially concerning tumor growth and metastasis. TEAD2's association with YAP and TAZ is significant in cancer biology due to their role in constitutive pathway activation which can lead to uncontrolled cell growth. Abnormal TEAD2 signaling may also influence diseases linked to developmental malformations because of its regulatory activity in important developmental pathways.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
See full target information TEAD2
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy. Nucleic acids 26:1215-1227 PubMed34853721

2021

PHF5A promotes colorectal cancerprogression by alternative splicing of TEAD2.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Chang,Yulu Zhao,Liya Wang,Meijuan Wu,Chenglong He,Mengxi Huang,Zengjie Lei,Jiahe Yang,Siqi Han,Bibo Wang,Yanyan Chen,Chao Liu,Hongju Yu,Lijun Xue,Jian Geng,Yanan Chen,Tingting Dai,Lili Ren,Qian Wang,Xiaobei Liu,Xiaoyuan Chu,Cheng Chen

Neoplasia (New York, N.Y.) 23:951-965 PubMed34343821

2021

mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics.

Applications

Unspecified application

Species

Unspecified reactive species

Brent Holmes,Angelica Benavides-Serrato,Jacquelyn T Saunders,Sunil Kumar,Robert N Nishimura,Joseph Gera

Aging 12:11530-11549 PubMed32541093

2020

Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Guanghua Liu,Jingmin Zhou,Yuanlin Piao,Xin Zhao,Yuzhi Zuo,Zhigang Ji

American journal of translational research 10:998-1011 PubMed29636889

2018

Effect of TEAD4 on multilineage differentiation of muscle-derived stem cells.

Applications

WB

Species

Cow

Jinze Wang,Feixu Zhang,Huidi Yang,Huikuan Wu,Rong Cui,Yunjie Zhao,Cuihua Jiao,Xianxin Wang,Xin Liu,Liqiong Wu,Guangpeng Li,Xia Wu
View all publications
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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