Anti-TANK/TRAF2 抗体 (ab47632)
Key features and details
- Rabbit polyclonal to TANK/TRAF2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-TANK/TRAF2 antibody -
製品の詳細
Rabbit polyclonal to TANK/TRAF2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human TANK/TRAF2.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab47632の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa).
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| 特記事項 |
|---|
|
WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 47 kDa). |
ターゲット情報
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機能
Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. -
組織特異性
Ubiquitous. -
配列類似性
Contains 1 C2H2-type zinc finger. -
翻訳後修飾
Phosphorylated by IKBKE. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 10010 Human
- Omim: 603893 Human
- SwissProt: Q92844 Human
- Unigene: 132257 Human
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別名
- I TRAF antibody
- I-TRAF antibody
- ITRAF antibody
see all
画像
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Western blot - Anti-TANK/TRAF2 antibody (ab47632)
Western Blot of human kidney lysate labeling TANK/TRAF2 with Anti-TANK/TRAF2 antibody (ab47632) at (1) 1 and (2) 2μg/ml.
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Western blot - Anti-TANK/TRAF2 antibody (ab47632)Lane 1 : Anti-TANK/TRAF2 antibody (ab47632) at 0.5 µg/ml
Lane 2 : Anti-TANK/TRAF2 antibody (ab47632) at 1 µg/ml
Lane 3 : Anti-TANK/TRAF2 antibody (ab47632) at 2 µg/ml
All lanes : Daudi Cell Lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 47 kDa
Observed band size: 55 kDa why is the actual band size different from the predicted?
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab47632 は 1 報の論文で使用されています。
- Scrima N et al. Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates. Cell Rep 42:111949 (2023). PubMed: 36640307