AB155195

Anti-Tal1 抗体

Name: Anti-Tal1 抗体 (ab155195) | Abcam
Brand: Abcam Limited
SKU: AB155195
Price: 76000 JPY
Availability: InStock
Rating: 4 (1 reviews)

Anti-Tal1 antibody

(1 Review)

(6 Publications)

Rabbit Polyclonal TAL1 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TAL1 aa 250-350.

別名を表示する

BHLHA17, SCL, TCL5, TAL1, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, Stem cell protein, T-cell leukemia/lymphoma protein 5, bHLHa17

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)

Immunohistochemical analysis of paraffin-embedded A549 xenograft tissue staining Tal1 with ab155195 at 1/100 dilution.

Antigen Retrieval : EDTA based buffer, pH 8.0, 15min.

Supplier Data

Immunoprecipitation - Anti-Tal1 antibody (AB155195)

TAL1 antibody immunoprecipitates TAL1 protein in IP experiments.

IP Sample : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate.

A : HEK-293T whole cell lysate. 40 μg.

B : Control with 2 μg of preimmune rabbit IgG.

C : Immunoprecipitate of TAL1 protein by 2 μg of ab155195.

12% SDS-PAGE

The immunoprecipitated TAL1 protein was detected by ab155195 at 1/1000 dilution, followed by anti-rabbit IgG antibody.

All lanes:

Immunoprecipitation - Anti-Tal1 antibody (ab155195)

Predicted band size: 34 kDa

false

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue staining Tal1 at cytosol and nucleus with ab155195 at 1/500 dilution.

Antigen Retrieval : EDTA based buffer, pH 8.0, 15min.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Human

アプリケーション

WB, IHC-P, IP

applications

免疫原

Synthetic Peptide within Human TAL1 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.

P17542

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/100 - 1/500", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)." }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)." } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein Tal1 also known as T-cell acute lymphocytic leukemia protein 1 and SCL (stem cell leukemia) is a transcription factor of about 34 kDa. It plays a role in the regulation of hematopoiesis. Tal1 is expressed in hematopoietic cells and tissues like bone marrow thymus and fetal liver. It binds to specific DNA sequences to regulate gene expression essential for the development and function of blood cells.

Biological function summary

The Tal1 protein controls the differentiation and proliferation of hematopoietic stem cells and progenitor cells. It participates as a part of a multiprotein complex involving other transcription factors and cofactors such as GATA-1 and LMO2 which modulates gene expression during blood cell lineage commitment. Through these interactions Tal1 influences both myeloid and lymphoid lineage differentiation.

Pathways

Tal1 acts as an important regulator in the hematopoietic development pathway and is critical for the endothelial-to-hematopoietic transition. This transition is supported by interaction with the E2A proteins which stabilize the formation of the transcription complex needed for lineage-specific gene regulation. Tal1 also plays a role in the VEGF signaling pathway impacting vascular and blood development processes.

Tal1 significantly associates with T-cell acute lymphoblastic leukemia (T-ALL) and some types of anemia. Its deregulation often through chromosomal translocations or overexpression results in aberrant hematopoiesis contributing to leukemogenesis. In T-ALL Tal1 can interact with oncogenic proteins like LMO1 and LMO2 leading to the disruption of normal T-cell development and proliferation highlighting its involvement in the disease's molecular pathology.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

See full target information TAL1

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:30552 PubMed40836054

2025

Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration.

Applications

Unspecified application

Species

Unspecified reactive species

Doru Kwon,Hyun Woo Park,Byung Soh Min,Junjeong Choi

Journal of translational medicine 23:719 PubMed40598260

2025

Remdesivir inhibits endothelial activation and atherosclerosis by coupling TAL1 to TRAF6.

Applications

Unspecified application

Species

Unspecified reactive species

Hanning Zhang,Ruru Li,Qianqian Huo,Li Li,Min Li,Shunxin Hu,Changjie Ren,Zongyin Wu,Chenghu Zhang

Cancers 15: PubMed37174017

2023

Expression of Hemangioblast Proteins in von Hippel-Lindau Disease Related Tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Evelynn Vergauwen,Ramses Forsyth,Alexander Vortmeyer,Sven Gläsker

Scientific reports 12:7226 PubMed35508511

2022

The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshihiro Yamada,Yi Zhong,Shiho Miki,Akiko Taura,Terence H Rabbitts

Leukemia 34:746-758 PubMed31676828

2019

LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Goichi Tatsumi,Masahiro Kawahara,Ryusuke Yamamoto,Masakatsu Hishizawa,Katsuyuki Kito,Takayoshi Suzuki,Akifumi Takaori-Kondo,Akira Andoh

Genome biology 20:192 PubMed31500663

2019

CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Zhu,Nan Liu,Stuart H Orkin,Guo-Cheng Yuan

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Tal1 抗体

Anti-Tal1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)

Immunoprecipitation - Anti-Tal1 antibody (AB155195)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (6)

Abcam product promise