Anti-TAK1 抗体 (ab25879)
Key features and details
- Rabbit polyclonal to TAK1
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-TAK1 antibody
TAK1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TAK1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Affinity purified -
特記事項(精製)
Ion exchange chromatography purified IgG. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab25879の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 67 kDa. The antibody will recognise all 4 isoforms of TAK1. The variation in the MW may also be caused by protein hydrophobicity, migrational speed or post-translational modifications.
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特記事項 |
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WB
Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 67 kDa. The antibody will recognise all 4 isoforms of TAK1. The variation in the MW may also be caused by protein hydrophobicity, migrational speed or post-translational modifications. |
ターゲット情報
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機能
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B. -
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain. -
翻訳後修飾
Association with TAB1/MAP3K7IP1 promotes autophosphorylation and subsequent activation. Association with TAB2/MAP3K7IP2, itself associated with free unanchored Lys-63 polyubiquitin chain, promotes autophosphorylation and subsequent activation of MAP3K7. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation.
Ubiquitinated, leading to proteasomal degradation (By similarity). Requires 'Lys-63'-linked polyubiquitination for autophosphorylation and subsequent activation. 'Lys-63'-linked ubiquitination does not lead to proteasomal degradation. Deubiquitinated by CYLD, a protease that selectively cleaves 'Lys-63'-linked ubiquitin chains. Deubiquitinated by Y.enterocolitica YopP. - Information by UniProt
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参照データベース
- Entrez Gene: 313121 Rat
- SwissProt: P0C8E4 Rat
- Unigene: 24019 Rat
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別名
- M3K7_HUMAN antibody
- MAP3K 7 antibody
- Map3k7 antibody
see all
画像
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Lane 1 : Anti-TAK1 antibody (ab25879) at 1 µg/ml
Lane 2 : Anti-TAK1 antibody (ab25879) at 2 µg/ml
Lane 3 : Anti-TAK1 antibody (ab25879) at 4 µg/ml
All lanes : Rat Thymus Tissue Lysate (ab4041)
Predicted band size: 67 kDa
Observed band size: 50 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab25879 は 3 報の論文で使用されています。
- Liu L et al. Development of a Toll-Like Receptor-Based Gene Signature That Can Predict Prognosis, Tumor Microenvironment, and Chemotherapy Response for Hepatocellular Carcinoma. Front Mol Biosci 8:729789 (2021). PubMed: 34621787
- Karimy JK et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med 23:997-1003 (2017). PubMed: 28692063
- Liu W et al. Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Clin Cancer Res 13:5028-33 (2007). PubMed: 17785553