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AB243719

Anti-Syntaxin 6 抗体

Anti-Syntaxin 6 antibody - Golgi Membrane Marker

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(2 Publications)

Rabbit Polyclonal Syntaxin 6 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STX6 aa 50-200.

別名を表示する

Syntaxin-6, STX6

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syntaxin 6 antibody - Golgi Membrane Marker (AB243719)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syntaxin 6 antibody - Golgi Membrane Marker (AB243719)

Formalin-fixed, paraffin-embedded human cerebral cortex tissue stained for Syntaxin 6 using ab243719 at 1/20 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-Syntaxin 6 antibody - Golgi Membrane Marker (AB243719)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Syntaxin 6 antibody - Golgi Membrane Marker (AB243719)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for Syntaxin 6 (green) using ab243719 at 4 μg/ml in ICC/IF.

Western blot - Anti-Syntaxin 6 antibody - Golgi Membrane Marker (AB243719)
  • WB

Supplier Data

Western blot - Anti-Syntaxin 6 antibody - Golgi Membrane Marker (AB243719)

All lanes:

Western blot - Anti-Syntaxin 6 antibody - Golgi Membrane Marker (ab243719) at 0.4 µg/mL

Lane 1:

RT4 (human urinary bladder cancer cell line0 cell lysate

Lane 2:

U-251 MG (human brain glioma cell line) cell lysate

Lane 3:

Human plasma

Lane 4:

Human liver

Lane 5:

Human tonsil

Predicted band size: 29 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF, IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human STX6 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

O43752

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代替製品

Primary Antibodies

AB12370

Anti-Syntaxin 6 antibody [3D10] - Golgi Membrane Marker

Lab Essentials

Flow Cytometry - Anti-Syntaxin 6 antibody [3D10] - Golgi Membrane Marker (AB12370)

  • 4
  • 3
Primary Antibodies

AB140607

Anti-Syntaxin 6 antibody [EP7665] - Golgi Membrane Marker

RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syntaxin 6 antibody [EP7665] - Golgi Membrane Marker (AB140607)

  • 3
  • 3

組合せ製品

Primary Antibodies

AB151545

Anti-STAM2 antibody [EPR8688]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-STAM2 antibody [EPR8688] (AB151545)

  • 0
  • 0
Primary Antibodies

AB124767

Anti-M6PR (cation independent) antibody [EPR6599] - Lysosome Membrane Marker

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-M6PR (cation independent) antibody [EPR6599] - Lysosome Membrane Marker (AB124767)

  • 5
  • 7
Primary Antibodies

AB69639

Anti-TRIM59 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIM59 antibody (AB69639)

  • 4
  • 1
Primary Antibodies

AB134945

Anti-Syntaxin 16 antibody [EPR9156]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Syntaxin 16 antibody [EPR9156] (AB134945)

  • 5
  • 4
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Syntaxin 6 also known as STX6 functions as a SNARE protein involved in vesicle fusion processes. It has a molecular weight of about 31 kDa. You find it mainly in the trans-Golgi network and within endosomal compartments. Syntaxin 6 varies in expression across different tissues but exhibits strong presence in the brain and lung. This protein plays an important role in intracellular trafficking by mediating fusion of transport vesicles with their correct target membranes.
Biological function summary

Syntaxin 6 contributes to intracellular material transport and acts as a component of the SNARE complex which includes other proteins like Vti1a and VAMP4. These SNARE complexes facilitate vesicle docking and fusion important for cargo delivery. In particular Syntaxin 6 aids in routing proteins and lipids from the Golgi apparatus to their destinations supporting normal cellular function and maintenance of cellular organelles.

Pathways

Syntaxin 6 involves itself in endocytosis and the secretory pathway. It interacts with proteins such as syntaxin 16 and Vti1b coordinating vesicular traffic from the Golgi to endosomes and lysosomes. Proper function of these pathways maintains cellular homeostasis and impacts processes like hormone secretion and receptor recycling making Syntaxin 6 integral for efficient cellular communication and transport.

Dysregulation of Syntaxin 6 links to neurodevelopmental disorders and cancer progression. Abnormal Syntaxin 6 expression can affect neurotransmitter release highlighting its relationship with proteins like VAMP2 in neurological disorders. Further alterations in its function impact cellular proliferation contributing to oncogenic processes through interactions with proteins such as SNAP23. Understanding its role in these contexts emphasizes the need for further research to explore therapeutic implications.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.
See full target information STX6
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of healthcare engineering 2022:9121554 PubMed35494512

2022

Antitumor Activity of lncRNA NBAT-1 via Inhibition of miR-4504 to Target to WWC3 in Oxaliplatin-Resistant Colorectal Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Li,Xu Li

Journal of bone oncology 28:100360 PubMed33996428

2021

Hsa_circ_0010220 regulates miR-198/Syntaxin 6 axis to promote osteosarcoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoan Lu,Chuanwen Wang,Xiaolong Lv,Wen Dai
View all publications
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