AB63932

Anti-Syndecan 3 抗体

Anti-Syndecan 3 antibody

(1 Review)

(7 Publications)

Rabbit Polyclonal Syndecan 3 antibody. Suitable for WB and reacts with Rat samples. Cited in 7 publications.

別名を表示する

KIAA0468, SDC3, Syndecan-3, SYND3

1 Images

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Western blot - Anti-Syndecan 3 antibody (AB63932)

All lanes:

Western blot - Anti-Syndecan 3 antibody (ab63932) at 1 µg/mL

All lanes:

Rat kidney tissue lysate at 30 µg

Predicted band size: 45 kDa

Observed band size: 46 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Rat

アプリケーション

applications

免疫原

Synthetic Peptide within Human SDC3. The exact immunogen used to generate this antibody is proprietary information.

O75056

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>" } } }

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製品の詳細

This product is manufactured by BioVision, an Abcam company and was previously called 3824 Syndecan-3 Antibody. 3824-100 is the same size as the 100 µg size of ab63932.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA

出荷温度

Blue Ice

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Syndecan 3 also known as N-syndecan is a heparan sulfate proteoglycan with a molecular mass of around 120-150 kDa. It has a core protein containing three heparan sulfate chains essential for its function. Expressed mainly in the nervous system Syndecan 3 shows significant concentration in neurons and glial cells. This proteoglycan plays an important role in cell-cell and cell-matrix interactions and contributes to neural developmental processes.

Biological function summary

Syndecan 3 modulates cellular behaviors including proliferation differentiation and migration. It functions as a co-receptor for various growth factors and adhesion molecules. This interaction facilitates signaling pathways that influence neural structure and function. Syndecan 3 forms complexes with other cell surface molecules which enhance its ability to mediate cellular responses. These interactions are essential for the development and maintenance of the nervous system.

Pathways

Syndecan 3 interacts within important signaling cascades such as the Wnt and fibroblast growth factor (FGF) pathways. The Wnt pathway involves the regulation of gene expression critical for cellular processes while FGF pathways direct cell division and differentiation. Syndecan 3's interaction with proteins like FGF receptors highlights its role in these pathways. It aids in modulating the activity of related proteins coordinating integrative signals that ensure proper neuronal development.

Syndecan 3 relates to neurodegenerative conditions like Alzheimer's Disease and developmental disorders such as autism. In Alzheimer's Disease its association with amyloid beta precursor protein (APP) suggests a role in amyloid plaque formation. In autism changes in the expression of Syndecan 3 may influence neural connectivity and communication. These interactions emphasize the importance of Syndecan 3 in maintaining neuronal integrity and highlight its potential as a therapeutic target.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.

See full target information SDC3

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Journal of cardiovascular pharmacology 79:e103-e115 PubMed34654784

2021

A Role for Peroxisome Proliferator-Activated Receptor Gamma Agonists in Counteracting the Degeneration of Cardiovascular Grafts.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Kathrin Assmann,Daniel Goschmer,Yukiharu Sugimura,Agunda Chekhoeva,Mareike Barth,Alexander Assmann,Artur Lichtenberg,Payam Akhyari

Glia 66:801-812 PubMed29282769

2017

Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier.

Applications

Unspecified application

Species

Unspecified reactive species

Marie L Bang,Anya Vainshtein,Hyun-Jeong Yang,Yael Eshed-Eisenbach,Jerome Devaux,Hauke B Werner,Elior Peles

Investigative ophthalmology & visual science 56:3004-14 PubMed26024086

2015

Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.

Applications

Unspecified application

Species

Unspecified reactive species

Vivien Jane Coulson-Thomas,Shao-Hsuan Chang,Lung-Kun Yeh,Yvette May Coulson-Thomas,Yu Yamaguchi,Jeffrey Esko,Chia-Yang Liu,Winston Kao

PloS one 10:e0117404 PubMed25617766

2015

Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mari Tinholt,Benedicte Stavik,William Louch,Cathrine Rein Carlson,Marit Sletten,Wolfram Ruf,Grethe Skretting,Per Morten Sandset,Nina Iversen

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:14820-6 PubMed25378149

2014

Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons.

Applications

Unspecified application

Species

Mouse

Aaron Gordon,Konstantin Adamsky,Anya Vainshtein,Shahar Frechter,Jeffrey L Dupree,Jack Rosenbluth,Elior Peles

The Journal of biological chemistry 289:25211-26 PubMed25053416

2014

Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis.

Applications

IHC-FoFr

Species

Mouse

Vivien Jane Coulson-Thomas,Tarsis Ferreira Gesteira,Jeffrey Esko,Winston Kao

The American journal of pathology 180:693-702 PubMed22138583

2011

Placental syndecan expression is altered in human idiopathic fetal growth restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Amy Chui,Nurul Zainuddin,Gayathri Rajaraman,Padma Murthi,Shaun P Brennecke,Vera Ignjatovic,Paul T Monagle,Joanne M Said

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Syndecan 3 抗体

Anti-Syndecan 3 antibody

Western blot - Anti-Syndecan 3 antibody (AB63932)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (7)

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

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Secondary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise