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AB234160

Anti-Syndecan-1 抗体 [MI15]

Anti-Syndecan-1 antibody [MI15]

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(1 Publication)

Mouse Monoclonal Syndecan-1 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing SDC1 protein.

別名を表示する

CD138, SDC, SDC1, Syndecan-1, SYND1

1 Images
Flow Cytometry - Anti-Syndecan-1 antibody [MI15] (AB234160)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Syndecan-1 antibody [MI15] (AB234160)

Surface staining of human peripheral blood with ab234160 followed by a Goat anti-mouse-APC conjugated secondary. Gated on lymphocytes and monocytes.

関連する標識済み抗体及び組成の異なる製品 (5)

  • 519 FITC

    FITC Anti-Syndecan-1 antibody [MI15]

  • 578 PE

    PE Anti-Syndecan-1 antibody [MI15]

  • 675 PerCP

    PerCP Anti-Syndecan-1 antibody [MI15]

  • 387 mFluor™ UV375

    mFluor™ UV375 Anti-CD138 antibody [MI15]

  • 454 mFluor™ Violet 450

    mFluor™ Violet 450 Anti-CD138 antibody [MI15]

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

MI15

アイソタイプ

IgG1

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing SDC1 protein. The exact immunogen used to generate this antibody is proprietary information.

P18827

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
精製に関する特記事項
Purified from hybridoma culture supernatant. Purity is >95% by SDS-PAGE.
バッファー組成
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Syndecan-1 also known as CD138 is a transmembrane heparan sulfate proteoglycan with a molecular weight of approximately 30 to 80 kDa. The size variation arises from differences in its glycosaminoglycan chains. This protein resides predominantly on the surface of epithelial cells and plasma cells. Researchers commonly use the CD138 marker to identify these cells in biological samples. It plays a significant role in cell-cell and cell-matrix interactions acting as a co-receptor for a variety of growth factors cytokines and extracellular matrix proteins.
Biological function summary

Syndecan-1 participates in tissue repair inflammation and cell signaling ensuring epithelial integrity and communication. Syndecan-1 influences cell behavior by interacting with other components of the extracellular matrix and different membrane receptors. It is also involved in forming and regulating proteoglycan complexes at the cell surface. These complex interactions facilitate the modulation of cell proliferation migration and differentiation which are fundamental to maintaining tissue architecture and function.

Pathways

Syndecan-1 actively contributes to both the Wnt and FGF signaling pathways. Through its interaction with proteins such as miR-15 syndecan-1 modulates cellular responses essential for developmental processes and tissue homeostasis. The connection with these pathways allows syndecan-1 to integrate and relay extracellular signals impacting gene expression and cellular behavior. Its relationship with other proteins like A38 as a co-receptor emphasizes its role in finely tuning signaling cascades within cellular environments.

Syndecan-1 shows a connection to multiple myeloma and breast cancer. The overexpression of syndecan-1 in these conditions disrupts normal cellular functions and promotes tumorigenesis by aiding in the tumor cell's adhesion migration and invasion. Its interaction with proteins such as perCP further demonstrates its role in disease progression providing potential as a therapeutic target. These relationships make syndecan-1 an important focus for research in oncology and other fields of disease study.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed : 22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity).
See full target information SDC1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature nanotechnology 19:1224-1233 PubMed38802667

2024

Virus-like structures for combination antigen protein mRNA vaccination.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Zhang,Yanmei Li,Fengyuan Zeng,Changyong Mu,Change Liu,Lichun Wang,Xiaowu Peng,Liping He,Yanrui Su,Hongbing Li,An Wang,Lin Feng,Dongxiu Gao,Zhixiao Zhang,Gang Xu,Yixuan Wang,Rong Yue,Junbo Si,Lichun Zheng,Xiong Zhang,Fuyun He,Hongkun Yi,Zhongshu Tang,Gaocan Li,Kaili Ma,Qihan Li
View all publications
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代替製品

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Primary Antibodies

AB128936

Anti-Syndecan-1 antibody [EPR6454]

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Primary Antibodies

AB216458

Anti-Syndecan-1 antibody [EPR6454] - Low endotoxin, Azide free

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan-1 antibody [EPR6454] - Low endotoxin, Azide free (AB216458)

  • 0
  • 0
Primary Antibodies

AB226108

Anti-Syndecan-1 antibody [EPR6454] - BSA and Azide free

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan-1 antibody [EPR6454] - BSA and Azide free (AB226108)

  • 0
  • 0
Primary Antibodies

AB242394

Anti-Syndecan-1 antibody [SP152] - BSA and Azide free

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan-1 antibody [SP152] - BSA and Azide free (AB242394)

  • 5
  • 1

組合せ製品

Assay Kits

AB46506

Human Syndecan-1 ELISA Kit (CD138)

ELISA - Human Syndecan-1 ELISA Kit (CD138) (AB46506)

  • 0
  • 0
Primary Antibodies

AB64088

Anti-CD20 antibody [SP32]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant|KO Validated

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  • 5
  • 12
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB28364

Anti-CD31 antibody

BOND RX™ Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody (AB28364)

  • 4
  • 161
Primary Antibodies

AB134114

Anti-CD19 antibody [EPR5906]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

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