Anti-Synaptopodin 抗体 (ab117702)
Key features and details
- Rabbit polyclonal to Synaptopodin
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Synaptopodin antibody
Synaptopodin 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Synaptopodin -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat
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免疫原
Synthetic peptide from the C terminal region of Human Synaptopodin, conjugated to KLH.
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ポジティブ･コントロール
- Human perineural or perivascular process.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab117702の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
Use a concentration of 5 µg/ml.
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| 特記事項 |
|---|
|
IHC-P
Use a concentration of 5 µg/ml. |
ターゲット情報
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機能
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity. -
組織特異性
Expressed in cerebral cortex. -
配列類似性
Belongs to the synaptopodin family. -
翻訳後修飾
O-glycosylated.
Isoform 2 is phosphorylated on Ser-826, Thr-836, Ser-840 and Ser-871. -
細胞内局在
Cytoplasm > cytoskeleton. Cell junction > tight junction. Perikaryon. Cell projection > dendritic spine. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Asssociated with dendritic spines of a subset of synapses. - Information by UniProt
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参照データベース
- Entrez Gene: 11346 Human
- Entrez Gene: 104027 Mouse
- Entrez Gene: 60324 Rat
- Omim: 608155 Human
- SwissProt: Q8N3V7 Human
- SwissProt: Q8CC35 Mouse
- SwissProt: Q9Z327 Rat
- Unigene: 435228 Human
see all -
別名
- KIAA1029 antibody
- Synaptopodin antibody
- SYNPO antibody
- SYNPO_HUMAN antibody
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Synaptopodin antibody (ab117702)Human Perineural Processes, Formalin-Fixed, Paraffin-Embedded tissue, stained with ab117702 at 5µg/ml.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Synaptopodin antibody (ab117702)Human Perivascular Processes, Formalin-Fixed, Paraffin-Embedded tissue, stained with ab117702 at 5µg/ml.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab117702 は 5 報の論文で使用されています。
- Ogorevc M et al. Differences in Immunohistochemical and Ultrastructural Features between Podocytes and Parietal Epithelial Cells (PECs) Are Observed in Developing, Healthy Postnatal, and Pathologically Changed Human Kidneys. Int J Mol Sci 23:N/A (2022). PubMed: 35886848
- Kosovic I et al. Spatio-temporal patterning of different connexins in developing and postnatal human kidneys and in nephrotic syndrome of the Finnish type (CNF). Sci Rep 10:8756 (2020). PubMed: 32471989
- Che X et al. Long noncoding RNA MEG3 suppresses podocyte injury in diabetic nephropathy by inactivating Wnt/ß-catenin signaling. PeerJ 7:e8016 (2019). PubMed: 31799068
- Subramanian A et al. Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nat Commun 10:5462 (2019). PubMed: 31784515
- Zhang Q et al. Activation of the Nrf2-ARE Pathway Ameliorates Hyperglycemia-Mediated Mitochondrial Dysfunction in Podocytes Partly Through Sirt1. Cell Physiol Biochem 48:1-15 (2018). PubMed: 29996125