AB178412

Anti-Synaptophysin 抗体 [EPR1097-2]

Anti-Synaptophysin antibody [EPR1097-2] - Synaptic Marker

RabMAb
Recombinant
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(4 Publications)

Rabbit Recombinant Monoclonal Synaptophysin antibody. Suitable for WB and reacts with Rat, Human, Mouse samples. Cited in 4 publications.

別名を表示する

Synaptophysin, Major synaptic vesicle protein p38, SYP

2 Images

Lab

Western blot - Anti-Synaptophysin antibody [EPR1097-2] - Synaptic Marker (AB178412)

All lanes:

Western blot - Anti-Synaptophysin antibody [EPR1097-2] - Synaptic Marker (ab178412) at 1/1000 dilution

Lane 1:

Human brain lysate at 20 µg

Lane 2:

Mouse brain lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/2000 dilution

Predicted band size: 33 kDa

Observed band size: 38 kDa

false

Lab

Western blot - Anti-Synaptophysin antibody [EPR1097-2] - Synaptic Marker (AB178412)

All lanes:

Western blot - Anti-Synaptophysin antibody [EPR1097-2] - Synaptic Marker (ab178412) at 1/1000 dilution

All lanes:

Rat brain lysate at 15 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/2000 dilution

Predicted band size: 33 kDa

Observed band size: 38 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR1097-2

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Rat, Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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製品の詳細

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Synaptophysin also known as SYP is a glycoprotein approximately 38 kDa in size. It is expressed abundantly in the presynaptic vesicle membranes of neurons and in neuroendocrine cells. Synaptophysin serves as a marker for synaptic vesicles and neuroendocrine tumors. The protein plays a significant role in synaptic vesicle cycling processes engaging in the release and recycling of neurotransmitters.

Biological function summary

Synaptophysin contributes to synaptic transmission and is engaged in the formation and maintenance of the synaptic vesicle pools. It is a part of the complex involved in neuronal communication and might interact with other vesicular proteins to ensure efficient neurotransmitter exchange. Researchers often utilize anti-Synaptophysin antibodies such as Alexa Fluor 647 labeled ones for visualization under confocal microscopy.

Pathways

Synaptophysin operates within pathways involving neurotransmitter release and synaptic vesicle cycle. It connects to proteins like Synaptotagmin and SNAP-25 integral to the facilitation of synaptic transmission and exocytosis. These pathways ensure efficient signal conduction across neurons which is critical for normal nervous system functioning.

Synaptophysin shows a strong association with neurodegenerative diseases and certain cancers like neuroblastoma. Altered expression levels or dysfunction of Synaptophysin can serve as a diagnostic marker for these conditions. The protein is connected with proteins like Bcl-2 in neurodegenerative diseases affecting cell survival and apoptosis pathways.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).

See full target information SYP

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Cells 14: PubMed39851539

2025

miR-223 and Chromogranin A Affect Inflammatory Immune Cell Activation in Liver Metastasis of Neuroendocrine Neoplasms.

Applications

Unspecified application

Species

Unspecified reactive species

Lukas Geisler,Katharina Detjen,Teresa Hellberg,Marlene Kohlhepp,Carsten Grötzinger,Jana Knorr,Ines Eichhorn,Raphael Mohr,Theresa Holtmann,Bertram Wiedenmann,Frank Tacke,Christoph Roderburg,Alexander Wree

Frontiers in endocrinology 15:1331231 PubMed38694940

2024

Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting.

Applications

Unspecified application

Species

Unspecified reactive species

Felix Bolduan,Alexandra Wetzel,Yvonne Giesecke,Ines Eichhorn,Natalia Alenina,Michael Bader,Thomas E Willnow,Bertram Wiedenmann,Michael Sigal

Nature communications 14:3025 PubMed37230989

2023

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche.

Applications

Unspecified application

Species

Unspecified reactive species

Manqiang Lin,Kimberly Hartl,Julian Heuberger,Giulia Beccaceci,Hilmar Berger,Hao Li,Lichao Liu,Stefanie Müllerke,Thomas Conrad,Felix Heymann,Andrew Woehler,Frank Tacke,Nikolaus Rajewsky,Michael Sigal

Evidence-based complementary and alternative medic 2020:9145458 PubMed32308720

2020

Sesamin Promotes Neurite Outgrowth under Insufficient Nerve Growth Factor Condition in PC12 Cells through ERK1/2 Pathway and SIRT1 Modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Sasimol Udomruk,Chayanut Kaewmool,Thanyaluck Phitak,Peraphan Pothacharoen,Prachya Kongtawelert

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Synaptophysin 抗体 [EPR1097-2]

Anti-Synaptophysin antibody [EPR1097-2] - Synaptic Marker

Western blot - Anti-Synaptophysin antibody [EPR1097-2] - Synaptic Marker (AB178412)

Western blot - Anti-Synaptophysin antibody [EPR1097-2] - Synaptic Marker (AB178412)

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Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

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Abcam product promise