Anti-Synapsin I (phospho S603) 抗体 (ab13879)
Key features and details
- Rabbit polyclonal to Synapsin I (phospho S603)
- Suitable for: WB
- Isotype: IgG
製品の概要
-
製品名
Anti-Synapsin I (phospho S603) antibody
Synapsin I 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Synapsin I (phospho S603) -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
免疫原
Synthetic peptide corresponding to Bovine Synapsin I (phospho S603).
Database link: P17599 -
特記事項
Aliquots may be taken without freeze/thawing due to the presence of 50% glycerol.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.50
Constituents: 0.238% HEPES, 0.87% Sodium chloride, 0.01% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
The antibody was purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab13879の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/1000. Predicted molecular weight: 84.6 kDa.
|
| 特記事項 |
|---|
|
WB
1/1000. Predicted molecular weight: 84.6 kDa. |
ターゲット情報
-
機能
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. -
関連疾患
Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior. -
配列類似性
Belongs to the synapsin family. -
翻訳後修飾
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR. -
細胞内局在
Cell junction > synapse. Golgi apparatus. - Information by UniProt
-
別名
- Brain protein 4.1 antibody
- SYN 1 antibody
- SYN 1a antibody
see all
画像
-
Western blot - Anti-Synapsin I (phospho S603) antibody (ab13879)Right lane-ab13879 at 1/1000 dilution detecting synapsin I by Western blot. Left lane-Peptide block. Right lane-ab13879 at 1/1000 dilution detecting synapsin I by Western blot. Left lane-Peptide block.
データシートおよび資料
-
Datasheet download
参考文献 (3)
ab13879 は 3 報の論文で使用されています。
- Yan P et al. Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons. Cell Death Dis 13:786 (2022). PubMed: 36097267
- Arias-Cavieres A et al. Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction. Front Cell Neurosci 12:403 (2018). PubMed: 30459562
- Arias-Cavieres A et al. Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats. Front Mol Neurosci 11:429 (2018). PubMed: 30534053
