AB13498

Anti-Superoxide Dismutase 1 抗体

Name: Anti-Superoxide Dismutase 1 抗体 (ab13498) | Abcam
Brand: Abcam Limited
SKU: AB13498
Price: 72000 JPY
Availability: InStock
Rating: 5 (23 reviews)

Anti-Superoxide Dismutase 1 antibody

(23 Reviews)

(232 Publications)

Anti-Superoxide Dismutase 1 antibody (ab13498) is a rabbit polyclonal antibody for Western Blot, IP, IHC-P, IHC-Fr, ICC/IF, ELISA. Suitable for Coral, Cow, Dog, Drosophila, Fish, Hamster, Human, Mollusk, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Xenopus.

- Over 190 publications
- Trusted since 2004

別名を表示する

Superoxide dismutase [Cu-Zn], Hydrogen sulfide oxidase, Superoxide dismutase 1, hSod1, SOD1

2 Images

Supplier Data

Western blot - Anti-Superoxide Dismutase 1 antibody (AB13498)

Block : 1.5% BSA.

All lanes:

Western blot - Anti-Superoxide Dismutase 1 antibody (ab13498) at 0.2 µg/mL

All lanes:

HeLa (Human epithelial cell line from cervix adenocarcinoma) lysate at 15 µg

Secondary

All lanes:

Donkey Anti-Rabbit IgG HRP 1 hr at RT

Predicted band size: 15 kDa

Observed band size: 23 kDa

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CiteAb

Western blot - Anti-Superoxide Dismutase 1 antibody (AB13498)

Western Blotting using Anti-Superoxide Dismutase 1 antibody, ab13498. Publication image from Liu, Y. et al., 2018, Nat Commun, 30356100. Legend direct from paper.

HPV16 E7-induced LDHA nuclear translocation implicates in cervical cancer development. a, b, c LDHANLS increases tumor growth in xenograft nude mice model. Representative images (mouse NO. 1 with Vec on the left flank and WT on the right flank, and mouse NO. 1′ with NLS on the left flank and NES on the right flank) of HeLa LDHA KO with Vec/WT/NLS/NES putback xenograft mice (a). Dissected tumors in xenograft mice transplanted with HeLa LDHA KO with Vec/WT/NLS/NES putback cells (b) and the tumor volumes on day 30 were represented (c). d LDHANLS tumor shows an elevated H3K79me2, NRF2, SOD1, and MYC levels. The level of H3K79me2 and the expression of NRF2, SOD1, and MYC in two pairs of representative tumors were analyzed by western blotting. β-actin and histone H3 were used as loading control. e LDHA nuclear translocation are positively correlated with H3K79 trimethylation in K14-HPV16 transgenic mice. Representative IHC images of HPV16 E7 expression, LDHA localization, and H3K79me3 level at indicated time point in TALEN-mediated targeting E7 of K14-HPV16 transgenic mice. n = 3 per group. Scale bar, 50 µm. f HPV16 E7 levels, LDHA nuclear translocation and H3K79 trimethylation are positively correlated with each other in human cervical tumor tissues. The 52 cases were divided into four groups on the basis of their tumor HPV16 E7 expression scores. Horizontal lines represent the median. Data are shown as mean ± SEM. The p values were determined by two-tailed t-test. The values of p < 0.05 were considered statistically significant. *, **, and *** denote p < 0.05, p < 0.01, and p < 0.001, respectively. NS means non significant. g Proposed molecular mechanism model of a noncanonical role for LDHA in responds to HR-HPV infection. PYR, pyruvate, LAC, lactate,α-KB,α-ketobutyrate, andα-HB,α-hydroxybutyrate

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human, Monkey, Xenopus laevis, Cow, Fish, Coral, Pig, African green monkey, Sheep, Mouse, Hamster, Drosophila melanogaster, Mollusk, Rabbit, Dog, Rat

アプリケーション

WB, IP, ICC/IF, IHC-P, IHC-Fr, ELISA

applications

免疫原

Synthetic Peptide within Human SOD1. The exact immunogen used to generate this antibody is proprietary information.

P00441

style

left-column