JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB103807

Anti-STK36 抗体

Anti-STK36 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal STK36 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human STK36.

別名を表示する

KIAA1278, STK36, Serine/threonine-protein kinase 36, Fused homolog

2 Images
Western blot - Anti-STK36 antibody (AB103807)
  • WB

Unknown

Western blot - Anti-STK36 antibody (AB103807)

All lanes:

Western blot - Anti-STK36 antibody (ab103807) at 5 µg/mL

All lanes:

Jurkat cell lysate at 50 µg

Predicted band size: 144 kDa

false

Western blot - Anti-STK36 antibody (AB103807)
  • WB

Unknown

Western blot - Anti-STK36 antibody (AB103807)

All lanes:

Western blot - Anti-STK36 antibody (ab103807) at 5 µg/mL

All lanes:

Mouse testis tissue lysate at 50 µg

Predicted band size: 144 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human STK36.

Q9NRP7

style
left-column

組合せ製品

Primary Antibodies

AB179475

Anti-Integrin alpha V antibody [EPR16800]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-Integrin alpha V antibody [EPR16800] (AB179475)

  • 5
  • 10
Primary Antibodies

AB221557

Anti-ARNTL2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ARNTL2 antibody (AB221557)

  • 0
  • 0
Primary Antibodies

AB229329

Anti-TIPIN antibody

Western blot - Anti-TIPIN antibody (AB229329)

  • 0
  • 0
Primary Antibodies

AB317604

Anti-PAI1 antibody [EPR21850-262]

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAI1 antibody [EPR21850-262] (AB317604)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

STK36 also known as serine/threonine kinase 36 is a protein with a molecular weight of approximately 134 kDa. It functions primarily as a kinase transferring phosphate groups from ATP to serine or threonine residues on target proteins. STK36 is expressed in various tissues with higher expression levels observed in the brain and testis. This expression suggests a significant role in cellular processes in these areas. STK36's activity is important for maintaining proper signaling pathways within cells.
Biological function summary

STK36 plays an essential role in the sonic hedgehog (SHH) signaling pathway which regulates embryonic development and cell differentiation. It acts as part of a complex that includes GLI transcription factors influencing their activity through phosphorylation. By regulating the activation of GLI proteins STK36 affects the transcription of genes involved in growth and morphogenesis. This regulatory mechanism highlights its influence on cellular development and division.

Pathways

The protein interacts mainly within the SHH signaling axis. It stabilizes the activity of the GLI transcription factors important for the expression of genes like PTCH1 and BCL2. Additionally STK36 operates within the context of the primary cilia a cellular structure where it works alongside proteins such as Smoothened (SMO) to mediate signal transduction. Through its pathway interactions STK36 directly affects the development and function of various cellular processes.

Mutations or dysregulation of STK36 have been linked to conditions such as medulloblastoma and hydrocephalus. In these contexts its interactions with proteins like the Suppressor of Fused (SUFU) become disrupted leading to aberrant SHH pathway activity. These diseases highlight the importance of STK36 in maintaining normal cellular signaling illustrating how its disruption can have profound pathological effects.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed : 10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed : 10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed : 10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.
See full target information STK36
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:8507-18 PubMed24948806

2014

An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dimphna H Meijer,Yu Sun,Tao Liu,Michael F Kane,John A Alberta,Guillaume Adelmant,Robert Kupp,Jarrod A Marto,David H Rowitch,Yoshihiro Nakatani,Charles D Stiles,Shwetal Mehta
View all publications
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com