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AB97530

Anti-STK17A 抗体

Anti-STK17A antibody

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(3 Publications)

Rabbit Polyclonal STK17A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STK17A aa 1-250.

別名を表示する

DRAK1, STK17A, Serine/threonine-protein kinase 17A, DAP kinase-related apoptosis-inducing protein kinase 1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK17A antibody (AB97530)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK17A antibody (AB97530)

Immunohistochemical analysis of paraffin-embedded SAS xenograft, using ab97530 at 1/500 dilution.

Western blot - Anti-STK17A antibody (AB97530)
  • WB

Unknown

Western blot - Anti-STK17A antibody (AB97530)

7.5% SDS PAGE

All lanes:

Western blot - Anti-STK17A antibody (ab97530) at 1/1000 dilution

All lanes:

Hep G2 whole cell lysate at 30 µg

Predicted band size: 47 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human STK17A aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

Q9UEE5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

STK17A also known as DRAK1 is a serine/threonine-protein kinase with a mass of approximately 45 kDa. This protein performs a role in cellular signal transduction by phosphorylating serine and threonine residues on target substrates. STK17A is expressed in a variety of human tissues with significant expression in the brain heart and skeletal muscle indicating its widespread regulatory functions.
Biological function summary

The kinase activity of STK17A affects processes like apoptosis and cell migration. It does not form a complex with other proteins but can directly interact with them to exert its influence. Through these interactions STK17A can regulate cell survival and death which are important in development and homeostasis within an organism.

Pathways

STK17A acts in the apoptosis signaling pathway and is known to modulate JNK (c-Jun N-terminal kinase) signaling. In the apoptosis pathway STK17A can modify the response of cells to stress stimuli effectively controlling programmed cell death. It shows functional association with proteins such as caspases which carry out the execution phase of apoptosis thereby linking STK17A to these essential cellular processes.

Dysregulation of STK17A has connections to cancer and neurodegenerative disorders. In cancer altered STK17A expression or activity can contribute to inappropriate cell survival and proliferation making it a relevant marker or target in tumor biology. It associates with proteins like Bcl-2 which are involved in promoting cell survival. In neurodegenerative disorders such as Alzheimer's disease changes in STK17A expression or function might affect neuronal apoptosis contributing to the pathology of these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.
See full target information STK17A
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of personalized medicine 11: PubMed34575686

2021

Progression Risk Score Estimation Based on Immunostaining Data in Oral Cancer Using Unsupervised Hierarchical Clustering Analysis: A Retrospective Study in Taiwan.

Applications

Unspecified application

Species

Unspecified reactive species

Hui-Ching Wang,Leong-Perng Chan,Chun-Chieh Wu,Hui-Hua Hsiao,Yi-Chang Liu,Shih-Feng Cho,Jeng-Shiun Du,Ta-Chih Liu,Cheng-Hong Yang,Mei-Ren Pan,Sin-Hua Moi

Oncology reports 45: PubMed33955523

2021

Predictive significance of STK17A in patients with gastric cancer and association with gastric cancer cell proliferation and migration.

Applications

Unspecified application

Species

Unspecified reactive species

Zehua Wang,Chenyi Wang,Bing-Hua Jiang,Litong Shi,Shan Lin,Lei Wang,Ling-Zhi Liu,Jian-Ge Qiu,Yanru Qin,Yongxu Jia

Biochemical and biophysical research communications 441:612-617 PubMed24183720

2013

Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus.

Applications

Unspecified application

Species

Unspecified reactive species

M Guadalupe Martinez,Michele A Bialecki,Sandrine Belouzard,Sandra M Cordo,Nélida A Candurra,Gary R Whittaker
View all publications
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