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AB228139

Anti-Stathmin 1 抗体 [SP49], prediluted

Anti-Stathmin 1 antibody [SP49], prediluted

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(1 Publication)

Rabbit Recombinant Monoclonal Stathmin 1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication.

別名を表示する

C1orf215, LAP18, OP18, STMN1, Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, Op18, pp19

14 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human B-cell lymphoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human breast ductal cell carcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human bladder transitional cell carcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human stomach adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human endometrium adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human thymus tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human melanoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human pancreatic adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human reactive lymph node tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human HK lymphoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human cervical squamous cell carcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 antibody [SP49], prediluted (AB228139)

Formalin-fixed, paraffin-embedded human ovarian adenocarcinoma tissue stained for Stathmin 1 using ab228139 in immunohistochemical analysis.

関連する標識済み抗体及び組成の異なる製品 (9)

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

SP49

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1", "IHCP-species-notes": "<p>Pre-diluted / ready to use.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
精製に関する特記事項
Purified from TCS by protein A/G.
バッファー組成
pH: 7.6 Preservative: 0.1% Sodium azide Constituents: Tris buffered saline, 1% BSA
出荷温度
Blue Ice
長期保存温度
+4°C
保管に関する情報
Do Not Freeze
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Stathmin 1 also known as Oncoprotein 18 (Op18) is a cytoplasmic phosphoprotein weighing approximately 19 kDa. It functions primarily by regulating microtubule dynamics; it destabilizes microtubules and promotes depolymerization. Stathmin 1 achieves this by binding to tubulin heterodimers preventing their polymerization into microtubules. This protein is widely expressed in neurons immune cells and various cancer cell lines indicating its significant role in cellular processes.
Biological function summary

Stathmin 1 is important in cell cycle regulation and cell signaling. It does not operate as part of a larger protein complex but rather exerts its effects directly on microtubules. By overriding the stabilization of microtubules it ensures proper mitotic spindle function. This action is especially significant during the G2/M transition and mitosis contributing to the precise segregation of chromosomes.

Pathways

The regulation of microtubule dynamics by Stathmin 1 plays an important role in cell division and neuronal development. It is involved in the PI3K/AKT signaling pathway which ensures cell survival and proliferation. Stathmin 1 interacts with other regulatory proteins such as Tau which stabilizes microtubules offering a balance between dynamic instability and stabilization. This interaction highlights its involvement in cytoskeletal reorganization essential for both cancer progression and neuronal function.

The altered expression of Stathmin 1 is often associated with various cancers including breast and ovarian cancers. Overexpression leads to enhanced tumor growth and metastasis. It also plays a role in neurological disorders by affecting neuronal microtubules making it of particular interest in research on neurodegenerative diseases like Alzheimer's. Its interaction with proteins like Tau in the brain further connects it to these disorders as both are involved in microtubule modulation important for maintaining cell structure and function.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
See full target information STMN1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The journal of pathology. Clinical research 2:210-222 PubMed27785366

2016

Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET.

Applications

Unspecified application

Species

Unspecified reactive species

Fangjin Huang,Zhaoxuan Ma,Sara Pollan,Xiaopu Yuan,Steven Swartwood,Arkadiusz Gertych,Maria Rodriguez,Jayati Mallick,Sanica Bhele,Maha Guindi,Deepti Dhall,Ann E Walts,Shikha Bose,Mariza de Peralta Venturina,Alberto M Marchevsky,Daniel J Luthringer,Stephan M Feller,Benjamin Berman,Michael R Freeman,W Gregory Alvord,George Vande Woude,Mahul B Amin,Beatrice S Knudsen
View all publications
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代替製品

Primary Antibodies

AB199812

Alexa Fluor® 647 Anti-Stathmin 1 antibody [EP1573Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-Stathmin 1 antibody [EP1573Y] (AB199812)

  • 0
  • 0
Primary Antibodies

AB199735

Alexa Fluor® 488 Anti-Stathmin 1 antibody [EP1573Y]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-Stathmin 1 antibody [EP1573Y] (AB199735)

  • 0
  • 0
Primary Antibodies

AB221017

Anti-Stathmin 1 antibody [EP1573Y] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Stathmin 1 antibody [EP1573Y] - BSA and Azide free (AB221017)

  • 5
  • 1
Primary Antibodies

AB52630

Anti-Stathmin 1 antibody [EP1573Y]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Stathmin 1 antibody [EP1573Y] (AB52630)

  • 5
  • 5
Primary Antibodies

AB76583

Anti-Stathmin 1 (phospho S63) antibody [EPR1574]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Stathmin 1 (phospho S63) antibody [EPR1574] (AB76583)

  • 4
  • 1

組合せ製品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB18207

Anti-beta III Tubulin antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody - Neuronal Marker (AB18207)

  • 5
  • 67
Primary Antibodies

AB26

Anti-p53 antibody [PAb 240]

KO Validated|Lab Essentials

Western blot - Anti-p53 antibody [PAb 240] (AB26)

  • 4
  • 56

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