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AB168273

Anti-SSBP2 抗体

Anti-SSBP2 antibody

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(1 Publication)

Mouse Polyclonal SSBP2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SSBP2.

別名を表示する

SSDP2, SSBP2, Single-stranded DNA-binding protein 2, Sequence-specific single-stranded-DNA-binding protein 2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SSBP2 antibody (AB168273)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SSBP2 antibody (AB168273)

Immunofluorescence analysis of HeLa cells labeling SSBP2 with ab168273 at 10μg/ml.

Western blot - Anti-SSBP2 antibody (AB168273)
  • WB

Unknown

Western blot - Anti-SSBP2 antibody (AB168273)

All lanes:

Western blot - Anti-SSBP2 antibody (ab168273) at 1 µg/mL

Lane 1:

SSBP2 transfected 293T cell line at 15 µL

Lane 2:

Non-transfected 293T cell line at 15 µL

Predicted band size: 38 kDa

false

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, ICC/IF

applications

免疫原

Recombinant Full Length Protein corresponding to Human SSBP2.

P81877

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Single-stranded DNA-binding protein 2 (SSBP2) also known as hSSB2 is a protein with a molecular mass of approximately 38 kDa. This protein plays a role in binding to single-stranded DNA. It is highly expressed in hematopoietic tissues including bone marrow and blood cells. SSBP2 also shows distinct expression in multiple human tissues highlighting its importance across different cellular environments. Mechanistically SSBP2 stabilizes single-stranded DNA by preventing the formation of secondary structures which is critical during DNA replication and repair.
Biological function summary

SSBP2 functions as a part of the multi-protein complex important for DNA metabolism and maintenance of genomic stability. It plays a role in the transcriptional activation of several tumor suppressor genes by interacting with other single-stranded DNA-binding partners. The protein influences cell cycle regulation by modulating the expression of genes involved in cell division and proliferation. This biological action affirms SSBP2's contribution to maintaining normal cellular functions and preventing abnormal cellular growth.

Pathways

The involvement of SSBP2 in cell cycle regulation and DNA repair underlines its participation in pathways like p53 signaling and homologous recombination. SSBP2 connects with proteins like RPA which is central to DNA metabolism to ensure accurate DNA replication and repair. These interactions place SSBP2 in a critical position to respond to and repair DNA damage thereby maintaining cellular integrity and genomic stability.

SSBP2 has relevance in leukemia and breast cancer. Its reduced expression or inactivity correlates with the progression of these diseases. In leukemia SSBP2's interaction with tumor suppressor proteins such as pRB is significant. In breast cancer its dysregulation can lead to unchecked cell proliferation. Understanding these relationships provides insight into SSBP2's potential as a biomarker and therapeutic target in cancer research.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information SSBP2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed36769256

2023

Herpes Simplex Virus 1 (HSV-1) Infected Cell Protein 0 (ICP0) Targets of Ubiquitination during Productive Infection of Primary Adult Sensory Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Telvin L Harrell,David J Davido,Andrea S Bertke
View all publications
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Abcam product promise

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