Anti-Sprouty 4/Spry-4 抗体 (ab59785)
Key features and details
- Rabbit polyclonal to Sprouty 4/Spry-4
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Sprouty 4/Spry-4 antibody
Sprouty 4/Spry-4 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Sprouty 4/Spry-4 -
由来種
Rabbit -
特異性
This antibody reacts specifically with human 32 kDa Sprouty 4/Spry-4 protein.
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アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Chicken, Cow
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免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
Constituent: Whole serum -
Concentration information loading... -
精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab59785の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (1) |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
|
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. -
配列類似性
Belongs to the sprouty family.
Contains 1 SPR (sprouty) domain. -
ドメイン
The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. -
細胞内局在
Cytoplasm. Cell projection > ruffle membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 427643 Chicken
- Entrez Gene: 504593 Cow
- Entrez Gene: 81848 Human
- Entrez Gene: 24066 Mouse
- Omim: 607984 Human
- SwissProt: A2VDU1 Cow
- SwissProt: Q9C004 Human
- SwissProt: Q9WTP2 Mouse
see all -
別名
- Protein sprouty homolog 4 antibody
- Sprouty 4 antibody
- Sprouty homolog 4 antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (5)
ab59785 は 5 報の論文で使用されています。
- Guo J et al. SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2. Aging (Albany NY) 13:11665-11677 (2021). PubMed: 33879635
- Chai Z et al. miR-1908 as a novel prognosis marker of glioma via promoting malignant phenotype and modulating SPRY4/RAF1 axis. Oncol Rep 38:2717-2726 (2017). PubMed: 29048686
- Edmonds MD et al. MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. J Clin Invest 126:349-64 (2016). PubMed: 26657862
- Lee JY et al. Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells. Dev Reprod 20:171-7 (2016). WB . PubMed: 27660833
- Barbáchano A et al. SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. Oncogene 29:4800-13 (2010). WB ; Human . PubMed: 20543868
