Anti-SP110 抗体 (ab67221)
Key features and details
- Rabbit polyclonal to SP110
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-SP110 antibody
SP110 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SP110 -
由来種
Rabbit -
特異性
This product recognizes isoforms a, b and c. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
A 16 amino acid synthetic peptide derived from near the amino terminus of human SP1101. (GenBank accession no. NP_004501, isoform b).
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ポジティブ･コントロール
- SW480 cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab67221の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 80-95 kDa (predicted molecular weight: 79 kDa).
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| 特記事項 |
|---|
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WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 80-95 kDa (predicted molecular weight: 79 kDa). |
ターゲット情報
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機能
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). -
組織特異性
Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. -
関連疾患
Defects in SP110 are the cause of hepatic venoocclusive disease with immunodeficiency (VODI) [MIM:235550]. VODI is an autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells. -
配列類似性
Contains 1 bromo domain.
Contains 1 HSR domain.
Contains 1 PHD-type zinc finger.
Contains 1 SAND domain. -
翻訳後修飾
Phosphorylated (isoform 2). -
細胞内局在
Nucleus. Found in the nuclear body. - Information by UniProt
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参照データベース
- Entrez Gene: 3431 Human
- Omim: 604457 Human
- SwissProt: Q9HB58 Human
- Unigene: 145150 Human
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別名
- FLJ22835 antibody
- IFI 41 antibody
- IFI 75 antibody
see all
画像
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Western blot - Anti-SP110 antibody (ab67221)Lane 1 : Anti-SP110 antibody (ab67221) at 1 µg/ml
Lane 2 : Anti-SP110 antibody (ab67221) at 2 µg/ml
All lanes : SW480 cell lysate
Lysates/proteins at 15 µg per lane.
Secondary
All lanes : Anti rabbit secondary antibody
Predicted band size: 79 kDa
Observed band size: 80-95 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab67221 は 1 報の論文で使用されています。
- Molzan M et al. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol Cell Biol 30:4698-711 (2010). PubMed: 20679480