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リコンビナントRabMAb

Anti-Sorbitol Dehydrogenase 抗体 [EPR15857] (ab189248)

Submit a review Submit a question References (2)
Western blot - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
  • Western blot - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
  • Immunoprecipitation - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
  • Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR15857] to Sorbitol Dehydrogenase
  • Suitable for: IP, WB
  • Reacts with: Mouse, Rat, Human

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-Sorbitol Dehydrogenase antibody [EPR15857]
    Sorbitol Dehydrogenase 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR15857] to Sorbitol Dehydrogenase

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: IP, WBmore details

  • 種交差性

    交差種: Mouse, Rat, Human

  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ･コントロール

    • Human fetal kidney, human fetal liver, mouse kidney, mouse spleen, rat kidney, C6, Hela, PC-3 cell lysates,

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab189248の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
IP
1/50.
WB
1/1000 - 1/20000. Predicted molecular weight: 38 kDa.
特記事項
IP
1/50.
WB
1/1000 - 1/20000. Predicted molecular weight: 38 kDa.

ターゲット情報

  • 機能

    Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.

  • 組織特異性

    Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).

  • 配列類似性

    Belongs to the zinc-containing alcohol dehydrogenase family.

  • 細胞内局在

    Mitochondrion membrane. Cell projection > cilium > flagellum. Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • DHSO_HUMAN antibody
    • L iditol 2 dehydrogenase antibody
    • L-iditol 2-dehydrogenase antibody
    • OTTHUMP00000161939 antibody
    • SDH antibody
    • Sorbitol dehydrogenase 1 antibody
    • Sorbitol dehydrogenase antibody
    • SORD 1 antibody
    • SORD antibody
    • SORD1 antibody
    see all

画像

  • Western blot - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
    Western blot - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
    All lanes : Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248) at 1/20000 dilution

    Lane 1 : Human fetal kidney tissue lysate
    Lane 2 : Human fetal liver tissue lysate
    Lane 3 : Hela cell lysate
    Lane 4 : PC-3 cell lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 38 kDa

  • Western blot - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
    Western blot - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
    All lanes : Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248) at 1/5000 dilution

    Lane 1 : Mouse kidney tissue lysate
    Lane 2 : Mouse spleen tissue lysate
    Lane 3 : Rat kidney tissue lysate
    Lane 4 : C6 lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 38 kDa

  • Immunoprecipitation - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
    Immunoprecipitation - Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)

    Immunoprecipitation of Human fetal liver labeling Sorbitol Dehydrogenase with ab189248 at 1/50 dilution and Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000.

  • Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)
    Anti-Sorbitol Dehydrogenase antibody [EPR15857] (ab189248)

参考文献 (2)

ab189248 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab189248 は 2 報の論文で使用されています。

  • Dong HL  et al. Biallelic SORD pathogenic variants cause Chinese patients with distal hereditary motor neuropathy. NPJ Genom Med 6:1 (2021). PubMed: 33397963
  • Cortese A  et al. Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes. Nat Genet 52:473-481 (2020). PubMed: 32367058

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