AB121759

Anti-SON/DBP5 抗体

Name: Anti-SON/DBP5 抗体 (ab121759) | Abcam
Brand: Abcam Limited
SKU: AB121759
Price: 76000 JPY
Availability: InStock
Rating: 5 (1 reviews)

Anti-SON/DBP5 antibody

(1 Review)

(14 Publications)

Anti-SON/DBP5 antibody (ab121759) is a rabbit polyclonal antibody detecting SON/DBP5 in IHC-P. Suitable for Human.

別名を表示する

C21orf50, DBP5, KIAA1019, NREBP, HSPC310, HSPC312, SON, Protein SON, Bax antagonist selected in saccharomyces 1, Negative regulatory element-binding protein, Protein DBP-5, SON3, BASS1, NRE-binding protein

5 Images

Unknown

Immunocytochemistry - Anti-SON/DBP5 antibody (AB121759)

ab121759, at 4 μg/ml, staining SON/DBP5 (green) in PFA-fixed, Triton X-100 permbabilized U-251 MG cells, by Immunofluorescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Paraffin-embedded human prostate tissue staining SON/DBP5 with ab121759 at 1/200 dilution in immunohistochemical analysis. Moderate to strong positivity in nuclear speckles in glandular cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Paraffin-embedded human small intestine tissue staining SON/DBP5 with ab121759 at 1/200 dilution in immunohistochemical analysis. Moderate to strong postiivty in nuclear speckles in glandular cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Paraffin-embedded human tonsil tissue staining SON/DBP5 with ab121759 at 1/200 dilution in immunohistochemical analysis. Moderate to strong positivity in nuclear speckles in germinal center cells.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Paraffin-embedded human cerebellum tissue staining SON/DBP5 with ab121759 at 1/200 dilution in immunohistochemical analysis. Moderate to strong positivity in nuclear speckles in Purkinje cells.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P, ICC

applications

免疫原

Recombinant Fragment Protein within Human SON aa 1450-1600. The exact immunogen used to generate this antibody is proprietary information.

P18583

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "0.25-2 µg/mL", "ICC-species-notes": "<p></p>" } } }

style

left-column

製品の詳細

What is this antibody validated in?
Anti-SON/DBP5 antibody (ab121759) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence : 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed : 27545680).

See full target information SON

style

left-column

文献 (14)

Recent publications for all applications. Explore the full list and refine your search

eLife 13: PubMed40900123

2025

DNA methylation insulates genic regions from CTCF loops near nuclear speckles.

Applications

Unspecified application

Species

Unspecified reactive species

Shelby A Roseman,Allison P Siegenfeld,Ceejay Lee,Nicholas Z Lue,Amanda L Waterbury,Brian B Liau

Nature communications 16:390 PubMed39755675

2025

Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention.

Applications

Unspecified application

Species

Unspecified reactive species

Alexa B R McIntyre,Adrian Beat Tschan,Katrina Meyer,Severin Walser,Arpan Kumar Rai,Keisuke Fujita,Lucas Pelkmans

Nature cell biology 27:322-335 PubMed39747580

2025

Nuclear speckles regulate functional programs in cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine A Alexander,Ruofan Yu,Nicolas Skuli,Nathan J Coffey,Son Nguyen,Christine L Faunce,Hua Huang,Ian P Dardani,Austin L Good,Joan Lim,Catherine Y Li,Nicholas Biddle,Eric F Joyce,Arjun Raj,Daniel Lee,Brian Keith,M Celeste Simon,Shelley L Berger

Communications biology 7:763 PubMed38914653

2024

Probing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Teng Hsiao,I-Hsin Liao,Bo-Kuan Wu,Hsueh-Ping Catherine Chu,Chia-Lung Hsieh

Journal of virology 98:e0190123 PubMed38629840

2024

Influenza A virus NS1 effector domain is required for PA-X-mediated host shutoff in infected cells.

Applications

Unspecified application

Species

Unspecified reactive species

Juliette Bougon,Eileigh Kadijk,Lucie Gallot-Lavallee,Bruce A Curtis,Matthew Landers,John M Archibald,Denys A Khaperskyy

Cell stem cell 30:1658-1673.e10 PubMed38065069

2023

SON is an essential mA target for hematopoietic stem cell fate.

Applications

Unspecified application

Species

Unspecified reactive species

Hanzhi Luo,Mariela Cortés-López,Cyrus L Tam,Michael Xiao,Isaac Wakiro,Karen L Chu,Aspen Pierson,Mandy Chan,Kathryn Chang,Xuejing Yang,Daniel Fecko,Grace Han,Eun-Young Erin Ahn,Quaid D Morris,Dan A Landau,Michael G Kharas

Frontiers in cell and developmental biology 11:1217637 PubMed37484912

2023

Quantitative super-resolution microscopy reveals the differences in the nanoscale distribution of nuclear phosphatidylinositol 4,5-bisphosphate in human healthy skin and skin warts.

Applications

Unspecified application

Species

Unspecified reactive species

Peter Hoboth,Martin Sztacho,Alexander Quaas,Baki Akgül,Pavel Hozák

PloS one 17:e0274091 PubMed36201559

2022

Epithelial cell size dysregulation in human lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Clifford W Sandlin,Song Gu,Jun Xu,Charuhas Deshpande,Michael D Feldman,Matthew C Good

MethodsX 8:101372 PubMed34430268

2021

Dual-color dSTORM imaging and ThunderSTORM image reconstruction and analysis to study the spatial organization of the nuclear phosphatidylinositol phosphates.

Applications

Unspecified application

Species

Unspecified reactive species

Peter Hoboth,Ondřej Šebesta,Martin Sztacho,Enrique Castano,Pavel Hozák

Molecular cell 81:1666-1681.e6 PubMed33823140

2021

p53 mediates target gene association with nuclear speckles for amplified RNA expression.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine A Alexander,Allison Coté,Son C Nguyen,Liguo Zhang,Omid Gholamalamdari,Paula Agudelo-Garcia,Enrique Lin-Shiao,K M A Tanim,Joan Lim,Nicolas Biddle,Margaret C Dunagin,Charly R Good,Mariel R Mendoza,Shawn C Little,Andrew Belmont,Eric F Joyce,Arjun Raj,Shelley L Berger

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SON/DBP5 抗体

Anti-SON/DBP5 antibody

Immunocytochemistry - Anti-SON/DBP5 antibody (AB121759)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SON/DBP5 antibody (AB121759)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

製品プロトコール

ターゲットの情報

文献 (14)

組合せ製品

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Abcam product promise